HitPredict

Interactor 1: VGLL2 (Q8N8G2)
Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1)
Gene: VGLL2

Interactor 2: TEAD3 (Q99594)
Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)
Gene: TEAD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Vg_Tdu~YBD
Common GO terms	GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 435
+	Hs
		1150209 VGLL2_HUMAN (1-317): 1.98e-117: 342: 100.00		TEAD4_HUMAN (1-435): 0: 712: 68.88
+	Mm
		717013 VGLL2_MOUSE (1-311): 1.47e-114: 335: 85.58		TEAD1_MOUSE (1-435): 0: 713: 70.81
+	Hs
		71141 VGLL3_HUMAN (1-282): 2.15e-65: 210: 34.17		TEAD3_HUMAN (1-435): 0: 716: 100.00
+	Hs
		71094 VGLL3_HUMAN (1-282): 2.15e-65: 210: 34.17		TEAD1_HUMAN (1-435): 0: 712: 70.58
+	Hs
		71108 VGLL3_HUMAN (1-282): 2.15e-65: 210: 34.17		TEAD4_HUMAN (1-435): 0: 712: 68.88
+	Mm
		1223984 VGLL1_MOUSE (70-271): 8.05e-59: 192: 22.13		TEAD4_MOUSE (1-435): 0: 707: 68.42
+	Hs
		1405587 VGLL1_HUMAN (72-271): 1.04e-55: 183: 31.00		TEAD3_HUMAN (1-435): 0: 716: 100.00
+	Hs
		1150217 VGLL1_HUMAN (72-271): 1.04e-55: 183: 31.00		TEAD4_HUMAN (1-435): 0: 712: 68.88
+	Hs
		703193 VGLL1_HUMAN (72-271): 1.04e-55: 183: 31.00		TEAD1_HUMAN (1-435): 0: 712: 70.58
+	Hs
		71109 VGLL3_HUMAN (1-282): 2.15e-65: 210: 34.17		TEAD2_HUMAN (32-435): 0: 623: 64.03
+	Hs
		1150248 VGLL1_HUMAN (72-271): 1.04e-55: 183: 31.00		TEAD2_HUMAN (32-435): 0: 623: 64.03
+	Dm
		717023 VG_DROME (78-229): 1.82e-32: 126: 32.26		SCAL_DROME (24-435): 0: 554: 56.91