HitPredict

Interactor 1: VGLL3 (A8MV65)
Transcription cofactor vestigial-like protein 3 (Vgl-3)
Gene: VGLL3

Interactor 2: TEAD2 (Q15562)
Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)
Gene: TEAD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Vg_Tdu~YBD
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 447
+	Hs
		71094 VGLL3_HUMAN (1-326): 4.23e-133: 383: 100.00		TEAD1_HUMAN (14-447): 0: 707: 65.15
+	Hs
		71108 VGLL3_HUMAN (1-326): 4.23e-133: 383: 100.00		TEAD4_HUMAN (3-447): 0: 698: 62.64
+	Hs
		71141 VGLL3_HUMAN (1-326): 4.23e-133: 383: 100.00		TEAD3_HUMAN (22-447): 0: 671: 64.07
+	Hs
		1150209 VGLL2_HUMAN (1-266): 7.52e-72: 227: 34.74		TEAD4_HUMAN (3-447): 0: 698: 62.64
+	Mm
		717013 VGLL2_MOUSE (1-266): 5.23e-67: 214: 32.86		TEAD1_MOUSE (14-447): 0: 706: 65.38
+	Hs
		1331161 VGLL2_HUMAN (1-266): 7.52e-72: 227: 34.74		TEAD3_HUMAN (22-447): 0: 671: 64.07
+	Mm
		1223984 VGLL1_MOUSE (73-262): 9.87e-57: 187: 22.87		TEAD4_MOUSE (14-447): 0: 695: 62.79
+	Hs
		703193 VGLL1_HUMAN (75-241): 1.81e-43: 152: 31.61		TEAD1_HUMAN (14-447): 0: 707: 65.15
+	Hs
		1150248 VGLL1_HUMAN (75-241): 1.81e-43: 152: 31.61		TEAD2_HUMAN (1-447): 0: 705: 100.00
+	Hs
		1150217 VGLL1_HUMAN (75-241): 1.81e-43: 152: 31.61		TEAD4_HUMAN (3-447): 0: 698: 62.64
+	Hs
		1405587 VGLL1_HUMAN (75-241): 1.81e-43: 152: 31.61		TEAD3_HUMAN (22-447): 0: 671: 64.07
+	Dm
		717023 VG_DROME (81-191): 2.06e-26: 110: 28.83		SCAL_DROME (6-447): 0: 574: 53.93