HitPredict

Interactor 1: TEAD3 (Q99594)
Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)
Gene: TEAD3

Interactor 2: VGLL1 (Q99990)
Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU)
Gene: VGLL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	32296183, 10518497, unassigned1304, 20211142
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Vg_Tdu~YBD
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 258
+	Hs
		1150217 TEAD4_HUMAN (1-435): 0: 712: 68.88		VGLL1_HUMAN (1-258): 5.66e-131: 372: 100.00
+	Hs
		703193 TEAD1_HUMAN (1-435): 0: 712: 70.58		VGLL1_HUMAN (1-258): 5.66e-131: 372: 100.00
+	Hs
		1150248 TEAD2_HUMAN (32-435): 0: 623: 64.03		VGLL1_HUMAN (1-258): 5.66e-131: 372: 100.00
+	Mm
		1223984 TEAD4_MOUSE (1-435): 0: 707: 68.42		VGLL1_MOUSE (1-229): 6.16e-97: 287: 41.50
+	Mm
		717013 TEAD1_MOUSE (1-435): 0: 713: 70.81		VGLL2_MOUSE (12-209): 6.09e-66: 209: 28.37
+	Hs
		1331161 TEAD3_HUMAN (1-435): 0: 716: 100.00		VGLL2_HUMAN (12-198): 2.7e-51: 171: 29.90
+	Hs
		1150209 TEAD4_HUMAN (1-435): 0: 712: 68.88		VGLL2_HUMAN (12-198): 2.7e-51: 171: 29.90
+	Hs
		71141 TEAD3_HUMAN (1-435): 0: 716: 100.00		VGLL3_HUMAN (14-171): 8.37e-40: 141: 27.55
+	Hs
		71094 TEAD1_HUMAN (1-435): 0: 712: 70.58		VGLL3_HUMAN (14-171): 8.37e-40: 141: 27.55
+	Hs
		71108 TEAD4_HUMAN (1-435): 0: 712: 68.88		VGLL3_HUMAN (14-171): 8.37e-40: 141: 27.55
+	Hs
		71109 TEAD2_HUMAN (32-435): 0: 623: 64.03		VGLL3_HUMAN (14-171): 8.37e-40: 141: 27.55