HitPredict

Interactor 1: FNDC5 (Q8NAU1)
Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin]
Gene: FNDC5

Interactor 2: SPB12 (Q96P63)
Serpin B12
Gene: SERPINB12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Serpin~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 260 Hs			1 405
+	Hs
		424527 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		PAI2_HUMAN (1-405): 9.02e-167: 475: 37.50
+	Hs
		1332813 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		SPB13_HUMAN (1-405): 4.15e-158: 452: 42.47
+	Hs
		874823 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		SPB4_HUMAN (1-405): 3.88e-157: 449: 47.04
+	Hs
		713416 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		SPB3_HUMAN (1-405): 3.61e-155: 444: 44.58
+	Hs
		895457 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		SPB8_HUMAN (1-405): 1.05e-151: 435: 39.51
+	Hs
		369368 FNDC5_HUMAN (1-260): 1.88e-174: 482: 100.00		A1AT_HUMAN (2-405): 1.93e-136: 398: 28.71
+	Mm
		619984 FNDC5_MOUSE (1-260): 3.72e-159: 443: 89.23		SERPH_MOUSE (3-405): 7.39e-50: 175: 28.96