HitPredict

Interactor 1: Q8R0B5 (Q8R0B5)
Orthodenticle homeobox 2 (Otx2 protein)
Gene: Otx2

Interactor 2: MIXL1 (Q9WUI0)
Homeobox protein MIXL1 (Homeodomain protein MIX) (mMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein)
Gene: MIXL1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	20211142
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 297 Mm			1 231
+	Mm
		1353919 Q8VD35_MOUSE (1-297): 9.35e-69: 217: 97.31		MIXL1_MOUSE (1-231): 2.6e-47: 157: 100.00
+	Mm
		204350 Q8R0B5_MOUSE (1-297): 2.23e-71: 223: 100.00		ALX4_MOUSE (3-222): 9.23e-36: 132: 21.36
+	Mm
		204351 Q8VD35_MOUSE (1-297): 9.35e-69: 217: 97.31		ALX4_MOUSE (3-222): 9.23e-36: 132: 21.36
+	Hs
		733236 OTX2_HUMAN (1-297): 7.74e-70: 219: 96.63		OTX2_HUMAN (54-142): 1.66e-35: 129: 47.19
+	Mm
		1009778 OTX2_MOUSE (1-297): 2.69e-69: 218: 96.97		OTX2_MOUSE (54-142): 1.93e-35: 128: 47.19
+	Hs
		733273 OTX2_HUMAN (1-297): 7.74e-70: 219: 96.63		NANOG_HUMAN (13-223): 3.36e-34: 126: 21.60
+	Mm
		1048208 Q8R0B5_MOUSE (1-297): 2.23e-71: 223: 100.00		EMX1_MOUSE (2-161): 3.37e-29: 111: 25.63
+	Mm
		1048210 Q8VD35_MOUSE (1-297): 9.35e-69: 217: 97.31		EMX1_MOUSE (2-161): 3.37e-29: 111: 25.63
+	Mm
		1009779 OTX2_MOUSE (1-297): 2.69e-69: 218: 96.97		DMBX1_MOUSE (86-144): 1.48e-13: 70.9: 59.32
+	Mm
		1353905 Q8VD35_MOUSE (1-297): 9.35e-69: 217: 97.31		DMBX1_MOUSE (86-144): 1.48e-13: 70.9: 59.32
+	Mm
		204323 RX_MOUSE (14-217): 7.41e-37: 136: 29.90		ALX4_MOUSE (3-222): 9.23e-36: 132: 21.36
+	Hs
		1152409 ALX1_HUMAN (18-245): 6.01e-37: 135: 24.68		ALX4_HUMAN (3-222): 2.07e-35: 131: 21.36
+	Mm
		204328 PAX3_MOUSE (20-280): 1.06e-33: 129: 24.72		ALX4_MOUSE (3-222): 9.23e-36: 132: 21.36
+	Dm
		478865 GSBN_DROME (41-229): 2.99e-37: 139: 29.63		UBX_DROME (29-146): 1.7e-31: 120: 22.88
+	Hs
		733239 LHX1_HUMAN (3-261): 4.44e-34: 129: 20.39		OTX2_HUMAN (54-142): 1.66e-35: 129: 47.19
+	Dm
		1014305 AL_DROME (10-253): 2.72e-36: 135: 24.50		UBX_DROME (29-146): 1.7e-31: 120: 22.88
+	Hs
		210085 CRX_HUMAN (1-297): 9.7e-36: 131: 45.71		RAX2_HUMAN (63-198): 1.1e-31: 116: 35.92
+	Mm
		1362451 DMBX1_MOUSE (44-168): 2.62e-37: 138: 42.06		DMBX1_MOUSE (86-144): 1.48e-13: 70.9: 59.32