Protein: OTX2
Homeobox protein OTX2 (Orthodenticle homolog 2)

Gene: OTX2
Organism: Homo sapiens
Interactions: 56
UniProt ID: P32243

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733240

ATX1
Ataxin-1

3

9

High-throughput

0.676

High

733236

OTX2
Homeobox protein OTX2

1

16

Small-scale

0.647

High

733239

LHX1
LIM/homeobox protein Lhx1

1

19

Small-scale

0.647

High

733244

PO5F1
POU domain, class 5, transcription factor 1

1

20

High-throughput

0.618

High

733273

NANOG
Homeobox protein NANOG

1

19

High-throughput

0.618

High

733277

AURKC
Aurora kinase C

2

8

High-throughput

0.615

High

47958

RBM47
RNA-binding protein 47

2

2

High-throughput

0.606

High

477931

SNRPA
U1 small nuclear ribonucleoprotein A

2

3

High-throughput

0.606

High

733237

HNF1B
Hepatocyte nuclear factor 1-beta

2

19

High-throughput

0.606

High

733241

KLF3
Krueppel-like factor 3

2

8

High-throughput

0.606

High

733243

CDK3
Cyclin-dependent kinase 3

2

7

High-throughput

0.606

High

733256

ZN765
Zinc finger protein 765

2

1

High-throughput

0.606

High

733266

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

1

High-throughput

0.606

High

733271

NAA50
N-alpha-acetyltransferase 50

2

1

High-throughput

0.606

High

421584

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

733278

FOXA2
Hepatocyte nuclear factor 3-beta

2

13

Small-scale

0.602

High

135782

RTCA
RNA 3'-terminal phosphate cyclase

2

0

High-throughput

0.580

High

164536

TNPO2
Transportin-2

2

0

High-throughput

0.580

High

211626

ZNHI1
Zinc finger HIT domain-containing protein 1

2

0

High-throughput

0.580

High

733238

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

0

High-throughput

0.580

High

733251

HIKES
Protein Hikeshi

2

0

High-throughput

0.580

High

733253

TM10B
tRNA methyltransferase 10 homolog B

2

0

High-throughput

0.580

High

733263

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.580

High

733275

JUPI1
Jupiter microtubule associated homolog 1

2

0

High-throughput

0.580

High

733242

RS26
Small ribosomal subunit protein eS26

2

2

High-throughput

0.553

High

733246

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

2

2

High-throughput

0.553

High

733252

TBCEL
Tubulin-specific chaperone cofactor E-like protein

2

2

High-throughput

0.553

High

733261

M1AP
Meiosis 1 arrest protein

2

2

High-throughput

0.553

High

733267

VATG3
V-type proton ATPase subunit G 3

2

1

High-throughput

0.553

High

733268

OR6C1
Olfactory receptor 6C1

2

2

High-throughput

0.553

High

733274

HOME3
Homer protein homolog 3

2

5

High-throughput

0.553

High

733276

GUC1B
Guanylyl cyclase-activating protein 2

2

1

High-throughput

0.553

High

549071

CDK4
Cyclin-dependent kinase 4

1

11

Small-scale

0.550

High

733245

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.541

High

733255

DDX46
Probable ATP-dependent RNA helicase DDX46

1

2

High-throughput

0.536

High

733280

DDX49
Probable ATP-dependent RNA helicase DDX49

1

4

High-throughput

0.536

High

733247

PAK1
Serine/threonine-protein kinase PAK 1

1

7

High-throughput

0.515

High

569065

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.513

High

445501

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.501

High

733257

ZDH17
Palmitoyltransferase ZDHHC17

1

11

High-throughput

0.494

High

733249

MAP7
Ensconsin

1

17

High-throughput

0.489

High

733264

RMXL1
RNA binding motif protein, X-linked-like-1

1

3

High-throughput

0.489

High

733270

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.481

High

733254

BCOR
BCL-6 corepressor

1

14

High-throughput

0.479

High

733262

Q8WUT1
POLDIP3 protein

1

2

High-throughput

0.470

High

733269

SORT
Sortilin

1

1

High-throughput

0.437

High

602198

TMM11
Transmembrane protein 11, mitochondrial

2

0

High-throughput

0.316

High

733258

OR1L3
Olfactory receptor 1L3

2

0

High-throughput

0.316

High

733259

B4GN2
Beta-1,4 N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.316

High

733260

RNS11
Putative inactive ribonuclease 11

2

0

High-throughput

0.316

High

733265

ASIC4
Acid-sensing ion channel 4

2

0

High-throughput

0.316

High

733272

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

0

High-throughput

0.316

High

733279

GPR45
Probable G-protein coupled receptor 45

2

0

High-throughput

0.316

High

733250

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

733248

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025