HitPredict

Interactor 1: PODXL (O00592)
Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
Gene: PODXL

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	11457882, 15642748, 11997330, 33961781, 35271311
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 558 Hs			1 337
+	Hs
		134424 PODXL_HUMAN (1-558): 6.78e-66: 225: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Oc
		1100192 PODXL_RABIT (1-558): 1.25e-48: 179: 42.36		NHRF2_RABIT (1-337): 2.53e-72: 228: 87.24
+	Mm
		936809 PODXL_MOUSE (35-558): 2.39e-49: 179: 40.27		NHRF1_MOUSE (2-337): 2.43e-68: 219: 48.88
+	Hs
		1075466 PDXL2_HUMAN (29-558): 3.21e-28: 120: 18.38		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153955 PDXL2_HUMAN (29-558): 3.21e-28: 120: 18.38		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Mm
		88458 D3Z656_MOUSE (5-390): 1.51e-12: 72.8: 10.61		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		1143433 SYNJ1_MOUSE (93-456): 4.13e-12: 71.3: 9.81		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1050035 CIC_HUMAN (2-447): 3.08e-09: 62.1: 10.31		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		203247 SYNJ1_HUMAN (170-505): 7.12e-11: 67.4: 9.77		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71