HitPredict

Interactor 1: DNM3B (Q9UBC3)
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)
Gene: DNMT3B

Interactor 2: DNM3A (Q9Y6K1)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)
Gene: DNMT3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.963

The method score is based on:

Property Details
Experiments 28514442, 14752048, 12867029, 12145218, 33961781, 20923784, 32968275
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, molecular sieving
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains ADD_DNMT3~ADD_DNMT3, DNA_methylase~DNA_methylase, PWWP~PWWP
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003714 - transcription corepressor activity
GO:0003886 - DNA (cytosine-5-)-methyltransferase activity
GO:0005634 - nucleus
and 4 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 853
Hs

1 912
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024