Protein: UHRF2
E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)

Gene: UHRF2
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q96PU4

Gene Ontology (top 5):
GO:0000792 - heterochromatin
GO:0003677 - DNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998702

H31
Histone H3.1

5

20

Small-scale

0.895

High

1110000

HDAC1
Histone deacetylase 1

4

20

Small-scale

0.893

High

667994

CDK2
Cyclin-dependent kinase 2

3

1

Small-scale

0.892

High

551209

PCNA
Proliferating cell nuclear antigen

3

4

Small-scale

0.865

High

906752

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

8

Small-scale

0.845

High

957173

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

8

Small-scale

0.845

High

1371615

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

8

Small-scale

0.829

High

685054

DNMT1
DNA

3

20

Small-scale

0.827

High

1399963

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

15

Small-scale

0.806

High

1399962

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

14

Small-scale

0.778

High

1399965

FACD2
Fanconi anemia group D2 protein

2

4

Small-scale

0.768

High

1396283

EHMT2
Histone-lysine N-methyltransferase EHMT2

2

8

Small-scale

0.754

High

440685

FYN
Tyrosine-protein kinase Fyn

1

7

Small-scale

0.724

High

443481

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.724

High

463711

LYN
Tyrosine-protein kinase Lyn

1

7

Small-scale

0.724

High

471752

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

1

Small-scale

0.724

High

549218

CDK4
Cyclin-dependent kinase 4

1

3

Small-scale

0.724

High

1025409

CDK6
Cyclin-dependent kinase 6

1

3

Small-scale

0.724

High

1060124

BAX
Apoptosis regulator BAX

1

2

Small-scale

0.724

High

1060290

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

2

Small-scale

0.724

High

982293

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

8

High-throughput

0.698

High

1383924

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

8

High-throughput

0.698

High

1399966

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.698

High

1399967

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

14

High-throughput

0.698

High

1399980

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

8

High-throughput

0.698

High

992308

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.687

High

440179

LCK
Tyrosine-protein kinase Lck

1

7

Small-scale

0.648

High

942830

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

Small-scale

0.648

High

1060211

B2CL1
Bcl-2-like protein 1

1

2

Small-scale

0.648

High

442791

RB
Retinoblastoma-associated protein

2

4

Small-scale

0.646

High

667007

CCNE1
G1/S-specific cyclin-E1

2

2

Small-scale

0.646

High

1358926

PCNP
PEST proteolytic signal-containing nuclear protein

3

0

Small-scale

0.636

High

1250582

DPPA3
Developmental pluripotency-associated protein 3

2

2

High-throughput

0.621

High

957651

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

10

High-throughput

0.621

High

157749

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.618

High

160202

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

17

Small-scale

0.618

High

260324

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.618

High

322673

KDM4B
Lysine-specific demethylase 4B

1

14

Small-scale

0.618

High

636132

CD11B
Cyclin-dependent kinase 11B

1

5

Small-scale

0.618

High

765811

BMI1
Polycomb complex protein BMI-1

1

13

Small-scale

0.618

High

993716

UBC9
SUMO-conjugating enzyme UBC9

1

12

Small-scale

0.618

High

1017132

H33
Histone H3.3

1

20

High-throughput

0.618

High

1088515

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

17

Small-scale

0.618

High

1114056

CUL3
Cullin-3

1

10

High-throughput

0.618

High

1115369

CUL4B
Cullin-4B

1

10

Small-scale

0.618

High

1141270

BRD3
Bromodomain-containing protein 3

1

20

Small-scale

0.618

High

1255131

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

1287976

PB1
Protein polybromo-1

1

20

Small-scale

0.618

High

1380096

FBXW7
F-box/WD repeat-containing protein 7

1

15

High-throughput

0.618

High

1399964

DIDO1
Death-inducer obliterator 1

1

18

Small-scale

0.618

High

1399968

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

18

Small-scale

0.618

High

1399974

PUF60
Poly(U)-binding-splicing factor PUF60

1

10

Small-scale

0.618

High

1399976

TLK1
Serine/threonine-protein kinase tousled-like 1

1

2

Small-scale

0.618

High

1399978

CD11A
Cyclin-dependent kinase 11A

1

5

Small-scale

0.618

High

1399979

KDM2A
Lysine-specific demethylase 2A

1

10

Small-scale

0.618

High

1399983

DNM3A
DNA

1

8

Small-scale

0.618

High

1290551

ZN410
Zinc finger protein 410

2

6

High-throughput

0.606

High

481364

HMGB1
High mobility group protein B1

2

19

Small-scale

0.603

High

414442

P53
Cellular tumor antigen p53

1

9

Small-scale

0.596

High

664792

CCND1
G1/S-specific cyclin-D1

1

3

Small-scale

0.596

High

1109491

ATR
Serine/threonine-protein kinase ATR

2

9

Small-scale

0.595

High

1399971

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.586

High

487649

PARP1
Poly [ADP-ribose] polymerase 1

2

14

Small-scale

0.584

High

558343

XRCC6
X-ray repair cross-complementing protein 6

2

7

Small-scale

0.584

High

559460

XRCC5
X-ray repair cross-complementing protein 5

2

7

Small-scale

0.584

High

1233864

DESI1
Desumoylating isopeptidase 1

2

0

High-throughput

0.580

High

573873

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.578

High

629155

CCNA2
Cyclin-A2

1

1

Small-scale

0.578

High

675636

TYY1
Transcriptional repressor protein YY1

1

8

Small-scale

0.561

High

764973

CTNB1
Catenin beta-1

1

17

Small-scale

0.561

High

911946

JAK3
Tyrosine-protein kinase JAK3

1

9

Small-scale

0.561

High

1055959

RAD51
DNA repair protein RAD51 homolog 1

1

6

Small-scale

0.561

High

1032036

TFAP4
Transcription factor AP-4

2

0

Small-scale

0.559

High

617727

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.554

High

572146

TRI27
Zinc finger protein RFP

1

5

High-throughput

0.541

High

927501

ATX1
Ataxin-1

1

2

High-throughput

0.541

High

1214446

ZN618
Zinc finger protein 618

1

0

Small-scale

0.537

High

75525

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

10

High-throughput

0.528

High

1398041

FXL18
F-box/LRR-repeat protein 18

1

0

Small-scale

0.517

High

689848

CD27
CD27 antigen

1

1

Small-scale

0.512

High

687287

HMGB2
High mobility group protein B2

1

20

Small-scale

0.508

High

1106671

SMAD4
Mothers against decapentaplegic homolog 4

1

4

High-throughput

0.508

High

1029912

RUNX1
Runt-related transcription factor 1

1

0

Small-scale

0.480

High

173740

BTAF1
TATA-binding protein-associated factor 172

1

19

Small-scale

0.479

High

285423

EED
Polycomb protein EED

1

20

Small-scale

0.479

High

330497

LC7L3
Luc7-like protein 3

1

6

Small-scale

0.479

High

331593

KIF4A
Chromosome-associated kinesin KIF4A

1

3

Small-scale

0.479

High

352227

MBD3
Methyl-CpG-binding domain protein 3

1

18

Small-scale

0.479

High

587192

ITF2
Transcription factor 4

1

2

Small-scale

0.479

High

611689

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.479

High

633333

MSH3
DNA mismatch repair protein Msh3

1

4

Small-scale

0.479

High

665131

COT2
COUP transcription factor 2

1

20

Small-scale

0.479

High

696258

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.479

High

711658

3MG
DNA-3-methyladenine glycosylase

1

1

Small-scale

0.479

High

761489

HS71L
Heat shock 70 kDa protein 1-like

1

6

Small-scale

0.479

High

887138

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

892605

DNLI3
DNA ligase 3

1

4

Small-scale

0.479

High

892918

MRE11
Double-strand break repair protein MRE11

1

4

Small-scale

0.479

High

913798

ZN131
Zinc finger protein 131

1

6

Small-scale

0.479

High

941529

CTBP2
C-terminal-binding protein 2

1

5

Small-scale

0.479

High

951815

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

1008292

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

Small-scale

0.479

High

1029140

E2F1
Transcription factor E2F1

1

6

Small-scale

0.479

High

1065374

SSRP1
FACT complex subunit SSRP1

1

19

Small-scale

0.479

High

1093033

CDC16
Cell division cycle protein 16 homolog

1

3

Small-scale

0.479

High

1094801

CAF1B
Chromatin assembly factor 1 subunit B

1

13

Small-scale

0.479

High

1137466

SUZ12
Polycomb protein SUZ12

1

8

Small-scale

0.479

High

1240680

CDC73
Parafibromin

1

2

Small-scale

0.479

High

1311270

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

8

Small-scale

0.479

High

1360991

P66B
Transcriptional repressor p66-beta

1

8

Small-scale

0.479

High

1371249

KAT5
Histone acetyltransferase KAT5

1

5

Small-scale

0.479

High

1399969

TF7L2
Transcription factor 7-like 2

1

20

Small-scale

0.479

High

1399970

ANLN
Anillin

1

1

High-throughput

0.479

High

1399972

BCLF1
Bcl-2-associated transcription factor 1

1

8

Small-scale

0.479

High

1399973

DNM3B
DNA

1

8

Small-scale

0.479

High

1399975

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1399977

RCOR1
REST corepressor 1

1

20

Small-scale

0.479

High

1399982

SP16H
FACT complex subunit SPT16

1

3

Small-scale

0.479

High

977801

ACTA
Actin, aortic smooth muscle

1

5

High-throughput

0.470

High

446539

DPOLB
DNA polymerase beta

1

0

Small-scale

0.458

High

808147

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.458

High

841235

CNDD3
Condensin-2 complex subunit D3

1

0

Small-scale

0.458

High

1109361

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

1252656

ZN574
Zinc finger protein 574

1

0

Small-scale

0.458

High

1293738

CNDG2
Condensin-2 complex subunit G2

1

0

Small-scale

0.458

High

1399981

LC7L2
Putative RNA-binding protein Luc7-like 2

1

6

Small-scale

0.437

High

130212

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

892495

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

Small-scale

0.249

Low

1157414

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025