HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 970 Hs			1 246
+	Hs
		136070 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		136072 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		136054 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		136069 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		136080 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433F_HUMAN (4-244): 2.72e-107: 311: 75.51
+	Hs
		136056 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62
+	At
		1030913 CIPKC_ARATH (2-450): 3.24e-157: 473: 24.57		14332_ARATH (1-241): 4.77e-145: 407: 63.27
+	At
		1379653 CIPKC_ARATH (2-450): 3.24e-157: 473: 24.57		14337_ARATH (1-239): 1.26e-144: 406: 61.73
+	At
		840534 CIPKC_ARATH (2-450): 3.24e-157: 473: 24.57		14333_ARATH (3-241): 4.46e-143: 402: 62.96
+	Hs
		729941 MRCKG_HUMAN (3-813): 1.21e-139: 456: 16.25		1433B_HUMAN (1-246): 3.49e-144: 404: 100.00
+	Hs
		990351 MRCKG_HUMAN (3-813): 1.21e-139: 456: 16.25		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		971486 ROCK1_HUMAN (5-620): 1.22e-134: 439: 19.42		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		691123 MRCKG_HUMAN (3-813): 1.21e-139: 456: 16.25		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		1049418 MRCKG_HUMAN (3-813): 1.21e-139: 456: 16.25		1433F_HUMAN (4-244): 2.72e-107: 311: 75.51
+	Hs
		730671 MRCKG_HUMAN (3-813): 1.21e-139: 456: 16.25		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62
+	Hs
		972069 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		919865 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		919861 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		730923 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62
+	Hs
		730462 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62