HitPredict

Interactor 1: P66B (Q8WXI9)
Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)
Gene: GATAD2B

Interactor 2: MBD2 (Q9UBB5)
Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)
Gene: MBD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.966

The method score is based on:

Property	Details
Experiments	12183469, 11756549, 26186194, 28514442, 24981860, 33961781, 40437099
Identification Methods	pull down, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	MBD_C~P66_CC
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling and 4 others more... GO:0016581 - NuRD complex GO:0032991 - protein-containing complex GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	593
Hs

1	411

Service provided by Combinatics, Japan

Last updated: 11Aug2025