HitPredict

Interactor 1: CCL17 (Q92583)
C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
Gene: CCL17

Interactor 2: CCL26 (Q9Y258)
C-C motif chemokine 26 (CC chemokine IMAC) (Eotaxin-3) (Macrophage inflammatory protein 4-alpha) (MIP-4-alpha) (Small-inducible cytokine A26) (Thymic stroma chemokine-1) (TSC-1)
Gene: CCL26

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	28381538
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007267 - cell-cell signaling GO:0008009 - chemokine activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 94 Hs			1 94
+	Hs
		518798 CCL4_HUMAN (4-91): 1.64e-33: 112: 27.27		CCL3_HUMAN (1-90): 1.5e-32: 110: 37.78
+	Hs
		561018 CCL4_HUMAN (4-91): 1.64e-33: 112: 27.27		CCL4_HUMAN (3-91): 2.3e-32: 109: 38.20
+	Hs
		1009600 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		CCL8_HUMAN (16-90): 1.05e-28: 100: 34.21
+	Hs
		124866 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		CCL24_HUMAN (1-93): 3.27e-28: 100: 32.98
+	Hs
		562853 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		CCL2_HUMAN (16-93): 9.63e-27: 95.8: 27.85
+	Hs
		1009604 CCL7_HUMAN (16-94): 7.11e-31: 106: 30.00		CCL7_HUMAN (16-93): 4.42e-29: 101: 35.44
+	Hs
		1009597 CCL8_HUMAN (15-94): 8.2e-31: 106: 23.46		CCL8_HUMAN (16-90): 1.05e-28: 100: 34.21
+	Hs
		1405935 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		CCL26_HUMAN (1-94): 2.9e-25: 91.9: 100.00
+	Hs
		562906 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		CCL5_HUMAN (14-90): 4e-25: 91.6: 37.66
+	Hs
		906852 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		CCL11_HUMAN (16-92): 6.21e-25: 91.2: 34.62
+	Hs
		562852 CC4L_HUMAN (14-91): 9.23e-32: 108: 28.21		CCL2_HUMAN (16-93): 9.63e-27: 95.8: 27.85
+	Hs
		562844 CCL8_HUMAN (15-94): 8.2e-31: 106: 23.46		CCL2_HUMAN (16-93): 9.63e-27: 95.8: 27.85
+	Hs
		562887 CCL8_HUMAN (15-94): 8.2e-31: 106: 23.46		CCL5_HUMAN (14-90): 4e-25: 91.6: 37.66
+	Hs
		906848 CCL8_HUMAN (15-94): 8.2e-31: 106: 23.46		CCL11_HUMAN (16-92): 6.21e-25: 91.2: 34.62
+	Hs
		906851 CCL14_HUMAN (1-91): 5.92e-31: 106: 29.67		CCL11_HUMAN (16-92): 6.21e-25: 91.2: 34.62
+	Hs
		869322 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		XCL1_HUMAN (6-92): 5.61e-21: 81.5: 29.89
+	Hs
		1009611 CCL7_HUMAN (16-94): 7.11e-31: 106: 30.00		XCL2_HUMAN (6-92): 2.15e-21: 82.7: 28.74
+	Hs
		142215 CCL14_HUMAN (1-91): 5.92e-31: 106: 29.67		CCL22_HUMAN (22-90): 8.02e-21: 80.4: 30.00
+	Hs
		141766 CCL13_HUMAN (6-94): 5.71e-34: 113: 29.21		CCL21_HUMAN (25-91): 5.28e-17: 71.9: 28.17