HitPredict

Interactor 1: ARC1A (Q92747)
Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)
Gene: ARPC1A

Interactor 2: ARP3B (Q9P1U1)
Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)
Gene: ACTR3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	26186194, 28514442, 33961781, 17353931, 24981860, unassigned3799
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~WD40
Common GO terms	GO:0003779 - actin binding GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 370 Hs			1 418
+	Hs
		958167 ARC1A_HUMAN (1-370): 9.78e-90: 276: 100.00		ARP3_HUMAN (1-418): 0: 571: 90.67
+	Hs
		179176 ARC1B_HUMAN (1-369): 1.91e-83: 260: 68.10		ARP3_HUMAN (1-418): 0: 571: 90.67
+	Hs
		953001 ARC1A_HUMAN (1-370): 9.78e-90: 276: 100.00		ACTB_HUMAN (1-414): 0: 526: 35.42
+	Hs
		179258 ARC1B_HUMAN (1-369): 1.91e-83: 260: 68.10		ARP3B_HUMAN (1-418): 0: 528: 100.00
+	Hs
		179175 ARC1B_HUMAN (1-369): 1.91e-83: 260: 68.10		ACTB_HUMAN (1-414): 0: 526: 35.42
+	Hs
		179188 ARC1B_HUMAN (1-369): 1.91e-83: 260: 68.10		ACTG_HUMAN (1-414): 0: 526: 35.18
+	Sp
		736410 ARPC1_SCHPO (5-357): 1.55e-71: 229: 43.73		ARP3_SCHPO (1-415): 2.65e-175: 498: 58.70
+	Hs
		995756 SNR40_HUMAN (129-369): 2.38e-45: 160: 14.52		ACTC_HUMAN (3-414): 0: 516: 35.84
+	Hs
		845262 LIS1_HUMAN (186-365): 3.44e-34: 132: 17.20		ACTB_HUMAN (1-414): 0: 526: 35.42
+	Hs
		845283 LIS1_HUMAN (186-365): 3.44e-34: 132: 17.20		ACTG_HUMAN (1-414): 0: 526: 35.18
+	Sc
		922103 COPA_YEAST (3-330): 1.29e-23: 104: 10.55		ACT_YEAST (1-414): 0: 520: 34.46
+	Dm
		357016 O97182_DROME (12-236): 1.36e-10: 64.1: 13.86		ARP3_DROME (1-418): 0: 557: 79.67
+	Hs
		952708 WDR5_HUMAN (1-82): 1e-10: 64.4: 11.49		ACTB_HUMAN (1-414): 0: 526: 35.42
+	Hs
		964830 WDR5_HUMAN (1-82): 1e-10: 64.4: 11.49		ACTG_HUMAN (1-414): 0: 526: 35.18
+	Dm
		357019 O97182_DROME (12-236): 1.36e-10: 64.1: 13.86		ACT3_DROME (3-414): 0: 518: 35.11
+	Sc
		798153 ARPC1_YEAST (96-365): 6.32e-12: 68.4: 12.68		ARP3_YEAST (6-417): 2.61e-173: 493: 57.46