HitPredict

Interactor 1: UNC89 (O01761)
Muscle M-line assembly protein unc-89 (Inactive serine/threonine-protein kinase unc-89) (Obscurin) (Uncoordinated protein 89)
Gene: unc-89

Interactor 2: RAC1 (Q03206)
Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1)
Gene: ced-10

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	18801371
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3, Pkinase~Ras, Ras~RhoGEF
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 8081 Ce			1 191
+	Ce
		104464 UNC89_CAEEL (1-8081): 0: 5676: 100.00		G5EBV3_CAEEL (2-191): 2.76e-79: 236: 62.63
+	Ce
		136794 UNC89_CAEEL (1-8081): 0: 5676: 100.00		CDC42_CAEEL (1-191): 2.85e-77: 230: 70.68
+	Ce
		136800 UNC89_CAEEL (1-8081): 0: 5676: 100.00		RHO1_CAEEL (5-191): 1.92e-73: 221: 56.68
+	Hs
		564764 ROBO1_HUMAN (6370-6592): 4.65e-21: 105: 20.96		RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87
+	Hs
		925776 ROBO1_HUMAN (6370-6592): 4.65e-21: 105: 20.96		RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81
+	Hs
		894644 ROBO1_HUMAN (6370-6592): 4.65e-21: 105: 20.96		CDC42_HUMAN (1-191): 1.95e-78: 233: 65.97
+	Hs
		901110 ROBO1_HUMAN (6370-6592): 4.65e-21: 105: 20.96		RHOA_HUMAN (5-191): 2.1e-77: 231: 56.15
+	Hs
		1331019 ROBO1_HUMAN (6370-6592): 4.65e-21: 105: 20.96		RHOJ_HUMAN (2-189): 3.05e-75: 226: 56.38
+	Hs
		256062 OBSL1_HUMAN (6399-6692): 5.23e-21: 105: 16.31		RHOJ_HUMAN (2-189): 3.05e-75: 226: 56.38
+	Hs
		436602 ROBO1_HUMAN (6370-6592): 4.65e-21: 105: 20.96		RHOC_HUMAN (5-191): 2.44e-75: 226: 54.55
+	Hs
		564637 NEO1_HUMAN (7515-7735): 3.41e-13: 79.6: 15.48		RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87
+	Hs
		894276 PXDN_HUMAN (1876-2263): 2.34e-11: 73.6: 23.06		CDC42_HUMAN (1-191): 1.95e-78: 233: 65.97
+	Hs
		1271865 NEO1_HUMAN (7515-7735): 3.41e-13: 79.6: 15.48		RHOJ_HUMAN (2-189): 3.05e-75: 226: 56.38
+	Hs
		900635 SDK1_HUMAN (7033-7825): 4.32e-10: 69.6: 10.77		RHOA_HUMAN (5-191): 2.1e-77: 231: 56.15
+	Hs
		894044 MYLK_HUMAN (4491-4583): 1.93e-09: 67.3: 26.60		CDC42_HUMAN (1-191): 1.95e-78: 233: 65.97