Protein: X3CL1
Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]

Gene: X3CL1, CX3CL1
Organism: Homo sapiens
Interactions: 81
UniProt ID: P78423

Gene Ontology (top 5):
GO:0001774 - microglial cell activation
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0002052 - positive regulation of neuroblast proliferation
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0002931 - response to ischemia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

880434

CX3C1
CX3C chemokine receptor 1

4

0

Small-scale

0.833

High

424024

ITB3
Integrin beta-3

2

4

Small-scale

0.612

High

1007896

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

2

1

High-throughput

0.601

High

1007858

X3CL1
Fractalkine

1

0

Small-scale

0.546

High

136367

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

2

High-throughput

0.536

High

410765

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.536

High

565595

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.536

High

648478

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.536

High

658682

JAK1
Tyrosine-protein kinase JAK1

1

2

High-throughput

0.536

High

775756

ATP7B
Copper-transporting ATPase 2

1

2

High-throughput

0.536

High

777665

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.536

High

931222

AT12A
Potassium-transporting ATPase alpha chain 2

1

1

High-throughput

0.536

High

1007862

ATP7A
Copper-transporting ATPase 1

1

2

High-throughput

0.536

High

1007871

FAT4
Protocadherin Fat 4

1

1

High-throughput

0.536

High

1007886

FAT3
Protocadherin Fat 3

1

1

High-throughput

0.536

High

1007889

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

2

High-throughput

0.536

High

1007895

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.536

High

1007901

S12A4
Solute carrier family 12 member 4

1

1

High-throughput

0.536

High

431784

ITB1
Integrin beta-1

1

4

Small-scale

0.515

High

71316

F1712
Protein FAM171A2

1

0

High-throughput

0.513

High

160257

GOSR2
Golgi SNAP receptor complex member 2

1

0

High-throughput

0.513

High

189507

STX7
Syntaxin-7

1

0

High-throughput

0.513

High

190598

MRP4
ATP-binding cassette sub-family C member 4

1

0

High-throughput

0.513

High

213315

ADCY6
Adenylate cyclase type 6

1

0

High-throughput

0.513

High

275884

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

High-throughput

0.513

High

331741

MTMR5
Myotubularin-related protein 5

1

0

High-throughput

0.513

High

557223

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

582155

INGR1
Interferon gamma receptor 1

1

0

High-throughput

0.513

High

602208

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.513

High

624627

SL9A1
Sodium/hydrogen exchanger 1

1

0

High-throughput

0.513

High

665084

COT2
COUP transcription factor 2

1

0

High-throughput

0.513

High

787144

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.513

High

874771

SPB4
Serpin B4

1

0

High-throughput

0.513

High

922418

CLH2
Clathrin heavy chain 2

1

0

High-throughput

0.513

High

1007859

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

0

High-throughput

0.513

High

1007860

AT8B2
Phospholipid-transporting ATPase ID

1

0

High-throughput

0.513

High

1007864

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.513

High

1007865

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

1007866

CEGT
Ceramide glucosyltransferase

1

0

High-throughput

0.513

High

1007867

WDR44
WD repeat-containing protein 44

1

0

High-throughput

0.513

High

1007869

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.513

High

1007870

RHDF2
Inactive rhomboid protein 2

1

0

High-throughput

0.513

High

1007872

PKHH3
Pleckstrin homology domain-containing family H member 3

1

0

High-throughput

0.513

High

1007874

LAP4B
Lysosomal-associated transmembrane protein 4B

1

0

High-throughput

0.513

High

1007875

ZDH13
Palmitoyltransferase ZDHHC13

1

0

High-throughput

0.513

High

1007876

ARL17
ADP-ribosylation factor-like protein 17

1

0

High-throughput

0.513

High

1007879

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.513

High

1007881

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.513

High

1007882

SMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

1

0

High-throughput

0.513

High

1007883

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.513

High

1007885

CERK1
Ceramide kinase

1

0

High-throughput

0.513

High

1007887

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.513

High

1007888

S35F5
Solute carrier family 35 member F5

1

0

High-throughput

0.513

High

1007892

PANX1
Pannexin-1

1

0

High-throughput

0.513

High

1007893

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.513

High

1007894

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

1007897

TEN3
Teneurin-3

1

0

High-throughput

0.513

High

1007900

STX8
Syntaxin-8

1

0

High-throughput

0.513

High

1007902

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.513

High

1007905

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.513

High

1007861

TF65
Transcription factor p65

1

0

Small-scale

0.493

High

1007863

STX5
Syntaxin-5

1

1

High-throughput

0.489

High

1007891

C1GLC
C1GALT1-specific chaperone 1

1

1

High-throughput

0.489

High

424069

ITB2
Integrin beta-2

1

4

Small-scale

0.479

High

592639

ITB4
Integrin beta-4

1

3

Small-scale

0.479

High

473692

ITA5
Integrin alpha-5

1

0

Small-scale

0.458

High

1007878

AN13A
Ankyrin repeat domain-containing protein 13A

1

0

High-throughput

0.426

High

1007898

SPRR3
Small proline-rich protein 3

1

0

High-throughput

0.426

High

1007904

T22D4
TSC22 domain family protein 4

1

0

High-throughput

0.426

High

1007880

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

2

0

High-throughput

0.313

High

230893

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.279

Low

322716

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.279

Low

692680

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

1007868

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

1007873

NOP9
Nucleolar protein 9

1

0

High-throughput

0.279

Low

1007877

DEN6A
Protein DENND6A

1

0

High-throughput

0.279

Low

1007884

WDR20
WD repeat-containing protein 20

1

0

High-throughput

0.279

Low

1007890

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.279

Low

1007899

TRM7
tRNA

1

0

High-throughput

0.279

Low

1007903

ZDHC9
Palmitoyltransferase ZDHHC9

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025