HitPredict

Interactor 1: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Interactor 2: KLH13 (Q9P2N7)
Kelch-like protein 13 (BTB and kelch domain-containing protein 2)
Gene: KLHL13

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	19615732, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 655
+	Hs
		1370426 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLHL9_HUMAN (44-655): 0: 548: 92.81
+	Hs
		1199628 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH22_HUMAN (38-651): 1.25e-147: 444: 32.38
+	Hs
		1235379 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH10_HUMAN (80-651): 1.16e-144: 435: 26.60
+	Hs
		1370425 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLHL8_HUMAN (441-653): 1.01e-48: 182: 28.04
+	Hs
		1247802 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH24_HUMAN (405-647): 7.27e-40: 156: 21.95
+	Hs
		1326615 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH36_HUMAN (425-646): 3.07e-39: 154: 21.30
+	Hs
		320835 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH18_HUMAN (469-648): 2.89e-39: 154: 23.08
+	Hs
		1370358 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLHL4_HUMAN (472-649): 1.04e-34: 142: 20.23
+	Hs
		1200002 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH26_HUMAN (427-643): 2e-27: 119: 16.67
+	Hs
		1199010 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH12_HUMAN (522-650): 3.88e-19: 93.4: 23.49
+	Hs
		1370305 CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00		KLH15_HUMAN (492-647): 1.04e-17: 89.1: 17.31
+	Hs
		138352 PSDE_HUMAN (50-331): 1.68e-79: 246: 31.51		IPP_HUMAN (487-648): 4.61e-32: 133: 22.35
+	Hs
		131538 EIF3F_HUMAN (44-328): 3.26e-64: 208: 14.48		KLH20_HUMAN (472-647): 7.87e-39: 153: 23.73