HitPredict

Interactor 1: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	26752685, 35927303, unassigned1260
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Peptidase_C65~UQ_con
Common GO terms	GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 151 Hs			1 271
+	Hs
		1391085 UB2D4_HUMAN (4-150): 2.13e-69: 207: 35.37		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		906745 UB2D1_HUMAN (4-150): 5.71e-69: 206: 34.69		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		982284 UB2D2_HUMAN (4-150): 3.15e-68: 204: 33.33		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		957165 UB2D3_HUMAN (4-150): 9.51e-67: 201: 33.33		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		1391011 UB2E2_HUMAN (1-150): 1.08e-65: 200: 34.67		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		1381181 UB2E3_HUMAN (1-150): 5.7e-65: 198: 35.33		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		909372 UB2E1_HUMAN (1-150): 1.19e-63: 195: 34.00		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Ce
		762745 UBC2_CAEEL (4-150): 1.95e-68: 205: 34.01		OTUBL_CAEEL (3-271): 2.77e-122: 352: 34.42
+	At
		1320254 UBC18_ARATH (4-149): 2.13e-59: 183: 50.00		OTU1_ARATH (31-270): 5.77e-113: 329: 42.37