HitPredict

Interactor 1: UNC5C (O08747)
Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) (Rostral cerebellar malformation protein)
Gene: UNC5C

Interactor 2: FLRT2 (Q8BLU0)
Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin leucine rich transmembrane protein 2)
Gene: FLRT2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	26633812
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	I-set~fn3, I-set~LRR_8, LRR_8~TSP_1
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0045202 - synapse GO:2001222 - regulation of neuron migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 931 Mm			1 660
+	Mm
		139750 UNC5C_MOUSE (1-931): 0: 985: 100.00		FLRT1_MOUSE (1-173): 3.04e-26: 116: 22.35
+	Hs
		1224475 UNC5B_HUMAN (36-930): 0: 886: 64.14		FLRT3_HUMAN (1-240): 3.73e-35: 143: 24.90
+	Mm
		1206871 UNC5B_MOUSE (49-930): 0: 871: 63.96		FLRT2_MOUSE (1-240): 3.88e-33: 137: 26.94
+	Mm
		1164192 UNC5B_MOUSE (49-930): 0: 871: 63.96		FLRT1_MOUSE (1-173): 3.04e-26: 116: 22.35
+	Mm
		1206872 UNC5A_MOUSE (48-930): 0: 841: 56.37		FLRT2_MOUSE (1-240): 3.88e-33: 137: 26.94
+	Dr
		69122 A9JR35_DANRE (33-930): 0: 816: 58.85		F1QF54_DANRE (1-285): 2.05e-37: 150: 21.38
+	Mm
		1164193 UNC5A_MOUSE (48-930): 0: 841: 56.37		FLRT1_MOUSE (1-173): 3.04e-26: 116: 22.35
+	Mm
		1206870 UNC5D_MOUSE (62-930): 0: 800: 50.33		FLRT2_MOUSE (1-240): 3.88e-33: 137: 26.94
+	Hs
		195862 UNC5D_HUMAN (50-930): 0: 789: 50.00		FLRT2_HUMAN (1-240): 8.57e-33: 136: 26.53
+	Dr
		47569 A9JR35_DANRE (33-930): 0: 816: 58.85		A0A8M9PLL4_DANRE (1-173): 5.75e-23: 106: 20.11
+	Mm
		1164191 UNC5D_MOUSE (62-930): 0: 800: 50.33		FLRT1_MOUSE (1-173): 3.04e-26: 116: 22.35
+	Dr
		69121 A9JR35_DANRE (33-930): 0: 816: 58.85		B8A507_DANRE (1-173): 1.67e-21: 100: 22.91
+	Dm
		219803 O44924_DROME (1-297): 4.52e-35: 147: 14.71		SLIT_DROME (162-481): 2.77e-42: 167: 23.93
+	Dm
		621597 Q9W213_DROME (1-297): 4.72e-35: 147: 14.71		SLIT_DROME (162-481): 2.77e-42: 167: 23.93
+	Dm
		621592 Q9GPP7_DROME (17-300): 6.17e-33: 140: 15.46		SLIT_DROME (162-481): 2.77e-42: 167: 23.93
+	Dm
		621596 Q9VQ08_DROME (17-300): 7.47e-33: 140: 15.46		SLIT_DROME (162-481): 2.77e-42: 167: 23.93
+	Dm
		621591 Q9GPP6_DROME (19-279): 5.3e-31: 133: 14.71		SLIT_DROME (162-481): 2.77e-42: 167: 23.93
+	Dm
		621595 Q9VPZ7_DROME (19-279): 5.21e-31: 133: 14.71		SLIT_DROME (162-481): 2.77e-42: 167: 23.93
+	Hs
		434617 TSP1_HUMAN (200-540): 3.06e-44: 175: 15.93		PGS1_HUMAN (36-272): 1.41e-20: 95.9: 27.59
+	Mm
		292557 ROBO1_MOUSE (22-586): 1.47e-37: 155: 12.87		SLIT3_MOUSE (28-242): 8.86e-21: 99.8: 24.36