HitPredict

Interactor 1: ERBIN (Q96RT1)
Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)
Gene: ERBIN

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	39115278, 34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1412 Hs			1 1620
+	Hs
		1399281 LRRC7_HUMAN (8-1411): 0: 652: 36.89		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		711931 ERBIN_HUMAN (8-1412): 0: 901: 100.00		LTK_HUMAN (606-1458): 2.7e-178: 559: 53.24
+	Hs
		464035 ERBIN_HUMAN (8-1412): 0: 901: 100.00		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		641241 ERBIN_HUMAN (8-1412): 0: 901: 100.00		FGFR2_HUMAN (952-1433): 1.46e-122: 406: 25.24
+	Hs
		710651 ERBIN_HUMAN (8-1412): 0: 901: 100.00		EPHA3_HUMAN (943-1427): 1.05e-119: 403: 25.05
+	Hs
		179629 ERBIN_HUMAN (8-1412): 0: 901: 100.00		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Hs
		1159526 ERBIN_HUMAN (8-1412): 0: 901: 100.00		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Hs
		1157034 ERBIN_HUMAN (8-1412): 0: 901: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Mm
		582000 ERBIN_MOUSE (8-1412): 0: 872: 88.34		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		1145768 LRRC7_HUMAN (8-1411): 0: 652: 36.89		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Mm
		581999 LRRC7_MOUSE (8-1411): 0: 662: 37.71		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	At
		1441316 BAME2_ARATH (4-868): 2.34e-116: 391: 15.38		NIK1_ARATH (878-1438): 3.62e-154: 487: 16.67
+	At
		1192471 BAME2_ARATH (4-868): 2.34e-116: 391: 15.38		ERECT_ARATH (548-1430): 3.53e-148: 482: 13.38
+	At
		1082486 BAME2_ARATH (4-868): 2.34e-116: 391: 15.38		Y2239_ARATH (862-1385): 8.03e-151: 477: 18.90
+	At
		89251 BAME2_ARATH (4-868): 2.34e-116: 391: 15.38		Y5457_ARATH (878-1413): 5.26e-148: 469: 18.10
+	At
		1354678 BAME2_ARATH (4-868): 2.34e-116: 391: 15.38		Y4052_ARATH (862-1385): 2.5e-147: 468: 18.50
+	At
		99930 BAME2_ARATH (4-868): 2.34e-116: 391: 15.38		F4I065_ARATH (928-1422): 1.08e-127: 423: 19.35
+	At
		99904 RGI4_ARATH (1-972): 2.11e-109: 374: 16.16		F4I065_ARATH (928-1422): 1.08e-127: 423: 19.35
+	At
		1441642 BAME2_ARATH (4-868): 2.34e-116: 391: 15.38		BRL3_ARATH (532-1043): 8.19e-23: 108: 10.57
+	At
		103548 RGI4_ARATH (1-972): 2.11e-109: 374: 16.16		RGI4_ARATH (634-1008): 5.05e-22: 106: 8.79