HitPredict - High confidence protein-protein interactions

Interactor 1: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Interactor 2: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18086888
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA_23~AAA_23
Common GO terms	GO:0000217 - DNA secondary structure binding GO:0000722 - telomere maintenance via recombination GO:0000724 - double-strand break repair via homologous recombination GO:0000775 - chromosome, centromeric region GO:0000781 - chromosome, telomeric region and 21 others more... GO:0000803 - sex chromosome GO:0003684 - damaged DNA binding GO:0003697 - single-stranded DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0016605 - PML body GO:0016607 - nuclear speck GO:0016887 - ATP hydrolysis activity GO:0016925 - protein sumoylation GO:0030915 - Smc5-Smc6 complex GO:0031625 - ubiquitin protein ligase binding GO:0032204 - regulation of telomere maintenance GO:0035061 - interchromatin granule GO:0035861 - site of double-strand break GO:0044828 - host-mediated suppression of viral genome replication GO:0051984 - positive regulation of chromosome segregation GO:0090398 - cellular senescence GO:0097431 - mitotic spindle pole GO:0140588 - chromatin looping
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	1091
Hs

1	1091

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Last updated: 11Aug2025