HitPredict

Interactor 1: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Interactor 2: RNF41 (Q9H4P4)
E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
Gene: RNF41

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	22493164
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 317
+	Hs
		623521 TRIM8_HUMAN (1-551): 1.57e-138: 414: 100.00		RO52_HUMAN (3-295): 9.72e-59: 197: 16.94
+	Hs
		1384945 TRIM8_HUMAN (1-551): 1.57e-138: 414: 100.00		TRI43_HUMAN (6-294): 2.69e-53: 182: 14.73
+	Hs
		1420186 TRIM8_HUMAN (1-551): 1.57e-138: 414: 100.00		TRI39_HUMAN (9-271): 1.2e-47: 168: 16.54
+	Hs
		572192 TRIM8_HUMAN (1-551): 1.57e-138: 414: 100.00		TRI27_HUMAN (3-275): 3.41e-46: 165: 14.75
+	Hs
		136725 TRIM8_HUMAN (1-551): 1.57e-138: 414: 100.00		TRAF5_HUMAN (8-132): 5.64e-29: 118: 29.13
+	Hs
		1348488 TRIM8_HUMAN (1-551): 1.57e-138: 414: 100.00		LNX1_HUMAN (8-121): 1.33e-26: 111: 27.27
+	Hs
		1357984 TRIM8_HUMAN (1-551): 1.57e-138: 414: 100.00		RN138_HUMAN (1-108): 1.78e-24: 100: 23.42
+	Hs
		623089 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		RO52_HUMAN (3-295): 9.72e-59: 197: 16.94
+	Hs
		623524 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		TRIM5_HUMAN (11-298): 6.41e-54: 185: 19.19
+	Hs
		623523 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		TRIM6_HUMAN (11-296): 7.22e-51: 176: 18.24
+	Hs
		1420569 TRIM6_HUMAN (1-521): 3.85e-88: 282: 13.03		TRIM5_HUMAN (11-298): 6.41e-54: 185: 19.19
+	Hs
		623551 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		TRI39_HUMAN (9-271): 1.2e-47: 168: 16.54
+	Hs
		571869 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		TRI27_HUMAN (3-275): 3.41e-46: 165: 14.75
+	Hs
		1420568 TRIM6_HUMAN (1-521): 3.85e-88: 282: 13.03		TRIM6_HUMAN (11-296): 7.22e-51: 176: 18.24
+	Hs
		623381 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		RC3H1_HUMAN (14-317): 9.36e-40: 150: 16.17
+	Hs
		572125 TRI11_HUMAN (2-522): 1.04e-86: 277: 15.30		TRI27_HUMAN (3-275): 3.41e-46: 165: 14.75
+	Hs
		623522 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		TRI31_HUMAN (3-315): 1.99e-38: 142: 15.46
+	Hs
		1418708 TRIM6_HUMAN (1-521): 3.85e-88: 282: 13.03		TRI34_HUMAN (5-298): 3.07e-41: 151: 17.43
+	Hs
		623455 RO52_HUMAN (1-535): 5.75e-94: 297: 13.47		LNX1_HUMAN (8-121): 1.33e-26: 111: 27.27