HitPredict

Interactor 1: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	17296600
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031519 - PcG protein complex
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 336 Mm			1 163
+	Hs
		992313 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		992147 RING1_HUMAN (10-336): 3.77e-66: 215: 51.75		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		765357 BMI1_HUMAN (34-332): 8.46e-43: 152: 16.83		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		992198 PCGF3_HUMAN (36-334): 1.93e-43: 151: 17.16		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		766078 PCGF2_HUMAN (34-332): 1.87e-40: 146: 15.84		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		992236 PCGF5_HUMAN (34-334): 1.64e-39: 141: 18.24		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		992323 TRI55_HUMAN (42-318): 3.35e-37: 141: 13.42		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		623261 RO52_HUMAN (36-249): 1.93e-36: 138: 13.08		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Dm
		305537 Q9VV77_DROME (36-334): 4.86e-45: 155: 18.69		O77430_DROME (1-163): 3.98e-82: 240: 76.07
+	Hs
		798968 BRCA1_HUMAN (36-213): 1.89e-33: 132: 25.93		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		992317 PCGF1_HUMAN (28-336): 8.33e-36: 132: 16.56		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		992322 PCGF6_HUMAN (29-293): 2.31e-31: 122: 15.67		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Zm
		27698 A0A1D6M7Z6_MAIZE (41-215): 2.28e-12: 70: 20.00		A0A1D6JK98_MAIZE (4-156): 8.9e-50: 164: 30.07