HitPredict

Interactor 1: Q9JHK1 (Q9JHK1)
Caspase-9 (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (ICE-like apoptotic protease 6)
Gene: Casp9

Interactor 2: XIAP (Q9R0I6)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (rIAP-3) (rIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27052476
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~zf-C3HC4_3, BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0032496 - response to lipopolysaccharide GO:0032991 - protein-containing complex and 1 others more... GO:0051402 - neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Rn			1 496
+	Hs
		936938 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		XIAP_HUMAN (1-496): 0: 581: 89.54
+	Hs
		1022717 CASP8_HUMAN (3-453): 4.78e-118: 355: 24.90		XIAP_HUMAN (1-496): 0: 581: 89.54
+	Mm
		148448 CASP9_MOUSE (1-454): 0: 527: 90.97		BIRC3_MOUSE (3-496): 1.39e-80: 264: 24.71
+	Hs
		936946 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		BIRC3_HUMAN (3-496): 2.45e-71: 239: 22.74
+	Hs
		1106875 CASP8_HUMAN (3-453): 4.78e-118: 355: 24.90		BIRC3_HUMAN (3-496): 2.45e-71: 239: 22.74
+	Hs
		712861 CASP1_HUMAN (1-451): 1.28e-116: 349: 21.17		BIRC3_HUMAN (3-496): 2.45e-71: 239: 22.74
+	Hs
		936964 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		BIRC7_HUMAN (16-152): 7e-32: 125: 21.74
+	Hs
		936954 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		Q6PIA0_HUMAN (160-263): 1.2e-30: 120: 30.48
+	Hs
		936965 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		BIRC8_HUMAN (160-263): 1.84e-30: 120: 30.48
+	Hs
		936971 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		BIRC6_HUMAN (254-441): 8.28e-26: 114: 18.50
+	Hs
		936943 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		BIRC1_HUMAN (3-103): 2.36e-24: 109: 35.64
+	Hs
		936947 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		BIRC2_HUMAN (404-496): 4.17e-23: 104: 39.79
+	Hs
		936962 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		RNF34_HUMAN (428-496): 1.59e-19: 92.2: 34.78
+	Hs
		188659 CASP9_HUMAN (1-454): 1.17e-150: 436: 71.59		BIRC5_HUMAN (265-368): 1.66e-20: 89.6: 29.73
+	Hs
		1132445 CASP8_HUMAN (3-453): 4.78e-118: 355: 24.90		BIRC6_HUMAN (254-441): 8.28e-26: 114: 18.50
+	Hs
		1132400 CASP8_HUMAN (3-453): 4.78e-118: 355: 24.90		RFFL_HUMAN (324-496): 7.76e-26: 110: 20.23
+	Hs
		840113 CASP2_HUMAN (1-453): 5.26e-120: 359: 27.68		BIRC2_HUMAN (404-496): 4.17e-23: 104: 39.79
+	Hs
		1107401 CASP8_HUMAN (3-453): 4.78e-118: 355: 24.90		BIRC2_HUMAN (404-496): 4.17e-23: 104: 39.79
+	Hs
		1132404 CASP8_HUMAN (3-453): 4.78e-118: 355: 24.90		RNF34_HUMAN (428-496): 1.59e-19: 92.2: 34.78
+	Hs
		712884 CASP1_HUMAN (1-451): 1.28e-116: 349: 21.17		RNF34_HUMAN (428-496): 1.59e-19: 92.2: 34.78