HitPredict

Interactor 1: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Interactor 2: BIRC1 (Q13075)
Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)
Gene: NAIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15280366
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005737 - cytoplasm GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 1403
+	Hs
		712878 CASP1_HUMAN (10-413): 3.54e-121: 359: 23.45		NAL10_HUMAN (342-888): 1.68e-117: 384: 15.74
+	Mm
		148448 CASP9_MOUSE (1-416): 3.73e-164: 470: 71.81		BIRC3_MOUSE (1-263): 8.26e-59: 216: 24.83
+	Hs
		936947 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		BIRC2_HUMAN (1-264): 5.94e-58: 214: 25.25
+	Hs
		936946 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		BIRC3_HUMAN (1-264): 2.36e-57: 211: 26.40
+	Hs
		936938 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		XIAP_HUMAN (2-131): 3.17e-38: 152: 21.37
+	Rn
		1440816 Q9JHK1_RAT (1-416): 8.5e-159: 457: 71.37		XIAP_RAT (2-131): 1.19e-40: 159: 21.54
+	Hs
		936964 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		BIRC7_HUMAN (3-128): 4.75e-31: 126: 27.14
+	Hs
		840113 CASP2_HUMAN (1-413): 2.58e-123: 366: 28.18		BIRC2_HUMAN (1-264): 5.94e-58: 214: 25.25
+	Hs
		936954 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		Q6PIA0_HUMAN (57-131): 5.1e-25: 107: 33.33
+	Hs
		936965 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		BIRC8_HUMAN (57-131): 6.79e-25: 106: 33.33
+	Hs
		712861 CASP1_HUMAN (10-413): 3.54e-121: 359: 23.45		BIRC3_HUMAN (1-264): 2.36e-57: 211: 26.40
+	Hs
		936968 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		NLRP1_HUMAN (1173-1385): 2.18e-17: 90.6: 16.28
+	Hs
		936972 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		NOD1_HUMAN (1181-1401): 4.99e-13: 76.4: 15.18
+	Hs
		936971 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		BIRC6_HUMAN (57-136): 5.59e-12: 73.3: 32.94
+	Hs
		188659 CASP9_HUMAN (1-416): 7.33e-163: 465: 100.00		BIRC5_HUMAN (63-127): 4.2e-10: 61.3: 32.86
+	Hs
		712886 CASP1_HUMAN (10-413): 3.54e-121: 359: 23.45		NLRP3_HUMAN (1028-1387): 3.72e-31: 135: 12.31
+	Hs
		712880 CASP1_HUMAN (10-413): 3.54e-121: 359: 23.45		NALP7_HUMAN (995-1385): 8.72e-22: 104: 15.50
+	Hs
		840124 CASP2_HUMAN (1-413): 2.58e-123: 366: 28.18		NLRP1_HUMAN (1173-1385): 2.18e-17: 90.6: 16.28
+	Hs
		840128 CASP2_HUMAN (1-413): 2.58e-123: 366: 28.18		NOD1_HUMAN (1181-1401): 4.99e-13: 76.4: 15.18
+	Hs
		712847 CASP1_HUMAN (10-413): 3.54e-121: 359: 23.45		NLRP6_HUMAN (1169-1384): 8.15e-10: 65.6: 12.89