HitPredict

Interactor 1: UBE2C (O00762)
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Gene: UBE2C

Interactor 2: KLHL2 (O95198)
Kelch-like protein 2 (Actin-binding protein Mayven)
Gene: KLHL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	25416956
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 179 Hs			1 593
+	Hs
		329049 UB2D1_HUMAN (31-176): 3.53e-79: 233: 36.30		KLHL2_HUMAN (1-593): 0: 563: 100.00
+	Hs
		329073 Q5TZN3_HUMAN (1-179): 5.29e-77: 229: 100.00		KLHL2_HUMAN (1-593): 0: 563: 100.00
+	Hs
		957228 UB2D3_HUMAN (31-176): 5.35e-78: 230: 34.93		KLHL3_HUMAN (12-593): 0: 538: 77.66
+	Hs
		906665 UB2D1_HUMAN (31-176): 3.53e-79: 233: 36.30		KEAP1_HUMAN (1-592): 3.16e-169: 497: 35.21
+	Hs
		884329 UBE2A_HUMAN (27-175): 1.02e-69: 210: 40.00		KEAP1_HUMAN (1-592): 3.16e-169: 497: 35.21
+	Hs
		906807 UB2D1_HUMAN (31-176): 3.53e-79: 233: 36.30		KLHL9_HUMAN (401-593): 2.82e-44: 168: 29.29
+	Hs
		906808 UB2D1_HUMAN (31-176): 3.53e-79: 233: 36.30		KLH13_HUMAN (497-590): 6.14e-12: 70.6: 24.75