HitPredict

Interactor 1: Q9VBI3 (Q9VBI3)
RH72336p (Vacuolar protein sorting 2)
Gene: Vps2

Interactor 2: CHMP5 (Q9VVI9)
Charged multivesicular body protein 5 (Vacuolar protein-sorting-associated protein 60)
Gene: Vps60

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0015031 - protein transport GO:0032509 - endosome transport via multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Dm			1 226
+	Hs
		221888 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHMP5_HUMAN (1-222): 1.85e-43: 147: 63.06
+	Ce
		1166323 Q9U2F6_CAEEL (1-256): 7.14e-48: 160: 63.28		Q18886_CAEEL (2-218): 1.6e-33: 121: 22.94
+	Dm
		1345394 Q9VBI3_DROME (1-256): 2.33e-43: 149: 100.00		CHM4_DROME (7-222): 1.35e-30: 114: 24.42
+	Dm
		1469210 Q9VBI3_DROME (1-256): 2.33e-43: 149: 100.00		Q9VN02_DROME (4-219): 4.79e-29: 110: 12.96
+	Hs
		221896 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHMP3_HUMAN (4-225): 1.04e-30: 114: 15.77
+	At
		1082317 VPS2A_ARATH (1-255): 5.86e-47: 157: 45.49		VPS2B_ARATH (7-219): 3.83e-25: 99.8: 15.96
+	At
		102954 F4JXR3_ARATH (1-229): 1.13e-44: 153: 14.55		VP322_ARATH (1-223): 2.5e-25: 100: 27.11
+	At
		307755 VP601_ARATH (1-229): 2.4e-42: 146: 16.46		VP321_ARATH (1-223): 2.97e-28: 107: 27.35
+	Sc
		781314 DID4_YEAST (2-256): 6.38e-41: 142: 39.45		DID4_YEAST (7-225): 1.43e-29: 111: 13.84
+	At
		307751 VPS2C_ARATH (3-212): 2.37e-42: 145: 30.48		VP321_ARATH (1-223): 2.97e-28: 107: 27.35
+	Dm
		1469211 Q9VBI3_DROME (1-256): 2.33e-43: 149: 100.00		Q9VRJ5_DROME (2-211): 2.75e-25: 100: 13.33
+	Hs
		221818 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHM2A_HUMAN (7-224): 8.52e-28: 106: 16.97
+	At
		1373936 VPS2C_ARATH (3-212): 2.37e-42: 145: 30.48		VP202_ARATH (1-213): 1.41e-26: 103: 19.01
+	Hs
		97297 E9PSI1_HUMAN (1-195): 1.15e-39: 147: 16.04		CHM4B_HUMAN (15-218): 3.53e-25: 100: 23.42
+	At
		1442471 VP601_ARATH (1-229): 2.4e-42: 146: 16.46		VP322_ARATH (1-223): 2.5e-25: 100: 27.11
+	At
		1082311 VP601_ARATH (1-229): 2.4e-42: 146: 16.46		VPS2B_ARATH (7-219): 3.83e-25: 99.8: 15.96
+	At
		1373941 VPS2C_ARATH (3-212): 2.37e-42: 145: 30.48		VP322_ARATH (1-223): 2.5e-25: 100: 27.11
+	At
		1299769 VPS2C_ARATH (3-212): 2.37e-42: 145: 30.48		VP201_ARATH (1-202): 3.74e-25: 99.9: 19.71
+	Hs
		221882 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHM4B_HUMAN (15-218): 3.53e-25: 100: 23.42
+	Sc
		781319 DID4_YEAST (2-256): 6.38e-41: 142: 39.45		SNF7_YEAST (3-211): 3.14e-25: 100: 24.53