HitPredict

Interactor 1: Q9VBI3 (Q9VBI3)
RH72336p (Vacuolar protein sorting 2)
Gene: Vps2

Interactor 2: Q9VN02 (Q9VN02)
GH14561p (Vacuolar protein sorting 24, isoform A) (Vacuolar protein sorting 24, isoform B)
Gene: Vps24

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.835

Property	Details
Experiments	14605208, 22036573, 38944040
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0015031 - protein transport GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0045324 - late endosome to vacuole transport
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 256 Dm			1 223
+	At
		1082317 VPS2A_ARATH (1-255): 5.86e-47: 157: 45.49		VPS2B_ARATH (1-222): 4.52e-50: 164: 24.32
+	Hs
		221896 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHMP3_HUMAN (1-223): 9.55e-53: 171: 58.74
+	At
		1082311 VP601_ARATH (1-229): 2.4e-42: 146: 16.46		VPS2B_ARATH (1-222): 4.52e-50: 164: 24.32
+	At
		1424668 VPS2A_ARATH (1-255): 5.86e-47: 157: 45.49		VP241_ARATH (7-223): 9.62e-46: 153: 40.72
+	Hs
		1462769 CHM2B_HUMAN (7-212): 4.1e-40: 139: 33.50		CHMP3_HUMAN (1-223): 9.55e-53: 171: 58.74
+	Sc
		781314 DID4_YEAST (2-256): 6.38e-41: 142: 39.45		DID4_YEAST (3-222): 1.3e-50: 166: 21.78
+	At
		102953 F4JXR3_ARATH (1-229): 1.13e-44: 153: 14.55		VP241_ARATH (7-223): 9.62e-46: 153: 40.72
+	Dm
		1469211 Q9VBI3_DROME (1-256): 2.33e-43: 149: 100.00		Q9VRJ5_DROME (2-209): 5.43e-45: 151: 27.40
+	At
		1424667 VP601_ARATH (1-229): 2.4e-42: 146: 16.46		VP241_ARATH (7-223): 9.62e-46: 153: 40.72
+	Hs
		221818 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHM2A_HUMAN (3-222): 1.37e-45: 152: 22.73
+	Hs
		1462767 CHM2B_HUMAN (7-212): 4.1e-40: 139: 33.50		CHM2B_HUMAN (9-204): 7.49e-45: 150: 22.45
+	Sc
		781005 DID4_YEAST (2-256): 6.38e-41: 142: 39.45		VPS24_YEAST (10-223): 4.85e-43: 146: 30.23
+	Dm
		1377973 Q9VBI3_DROME (1-256): 2.33e-43: 149: 100.00		Q95SH2_DROME (23-222): 3.93e-38: 132: 16.50
+	Hs
		221885 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHM1A_HUMAN (22-223): 2.67e-37: 130: 11.39
+	Hs
		221862 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		CHM1B_HUMAN (23-223): 2.59e-35: 125: 13.93
+	Hs
		1439653 CHMP3_HUMAN (4-194): 7.45e-39: 136: 23.83		CHM1A_HUMAN (22-223): 2.67e-37: 130: 11.39
+	Hs
		1273187 CHMP3_HUMAN (4-194): 7.45e-39: 136: 23.83		CHM1B_HUMAN (23-223): 2.59e-35: 125: 13.93
+	Sc
		781332 DID4_YEAST (2-256): 6.38e-41: 142: 39.45		DID2_YEAST (22-222): 4.33e-32: 117: 12.44