Protein: DID4
DOA4-independent degradation protein 4 (ESCRT-III complex subunit VPS2) (Vacuolar protein-sorting-associated protein 2) (Vacuolar protein-targeting protein 14)

Gene: DID4
Organism: Saccharomyces cerevisiae S288C
Interactions: 47
UniProt ID: P36108

Gene Ontology (top 5):
GO:0000815 - ESCRT III complex
GO:0005737 - cytoplasm
GO:0005771 - multivesicular body
GO:0015031 - protein transport
GO:0032509 - endosome transport via multivesicular body sorting pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

781319

SNF7
Vacuolar-sorting protein SNF7

7

20

Small-scale

0.958

High

781332

DID2
Vacuolar protein-sorting-associated protein 46

5

17

Small-scale

0.916

High

781336

VPS20
Vacuolar protein sorting-associated protein 20

4

20

Small-scale

0.885

High

781005

VPS24
Vacuolar protein-sorting-associated protein 24

4

19

Small-scale

0.873

High

781331

IST1
Vacuolar protein sorting-associated protein IST1

3

13

Small-scale

0.821

High

781335

VPS60
Vacuolar protein-sorting-associated protein 60

2

20

Small-scale

0.806

High

781314

DID4
DOA4-independent degradation protein 4

2

17

High-throughput

0.791

High

781326

YJE9
Uncharacterized protein YJL049W

2

2

Small-scale

0.757

High

781329

VPS4
Vacuolar protein sorting-associated protein 4

6

20

Small-scale

0.739

High

438138

NOT2
General negative regulator of transcription subunit 2

1

0

High-throughput

0.518

High

781323

MOB2
CBK1 kinase activator protein MOB2

1

0

High-throughput

0.518

High

781328

JSN1
Protein JSN1

1

0

High-throughput

0.518

High

781339

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.518

High

753063

NIP80
Protein NIP100

1

3

High-throughput

0.481

High

646655

VPS15
Serine/threonine-protein kinase VPS15

1

1

High-throughput

0.479

High

649815

VPS34
Phosphatidylinositol 3-kinase VPS34

1

2

High-throughput

0.479

High

781327

VPS55
Vacuolar protein sorting-associated protein 55

1

2

Small-scale

0.479

High

781334

BECN1
Vacuolar protein sorting-associated protein 30

1

1

High-throughput

0.479

High

781318

RV167
Reduced viability upon starvation protein 167

1

0

Small-scale

0.460

High

781324

NMD5
Nonsense-mediated mRNA decay protein 5

1

0

High-throughput

0.458

High

523620

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

526407

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

544479

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

758079

CASP
Protein CASP

1

1

High-throughput

0.439

High

582445

SEC23
Protein transport protein SEC23

1

3

High-throughput

0.437

High

624733

PMA2
Plasma membrane ATPase 2

1

1

High-throughput

0.437

High

705160

PEX3
Peroxisomal biogenesis factor 3

1

2

High-throughput

0.437

High

706794

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

781317

ATG14
Autophagy-related protein 14

1

1

High-throughput

0.437

High

781321

SEC24
Protein transport protein SEC24

1

3

High-throughput

0.437

High

781325

ATG27
Autophagy-related protein 27

1

2

High-throughput

0.437

High

781338

SEC13
Protein transport protein SEC13

1

2

High-throughput

0.437

High

781340

ATG23
Autophagy-related protein 23

1

2

High-throughput

0.437

High

781341

VPS68
Vacuolar protein sorting-associated protein 68

1

2

Small-scale

0.437

High

781342

TMS1
Membrane protein TMS1

1

2

Small-scale

0.437

High

781343

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

781315

SET3
SET domain-containing protein 3

1

2

High-throughput

0.407

High

781320

YEV1
Uncharacterized protein YER121W

1

0

High-throughput

0.282

High

781333

STD1
Protein STD1

1

0

High-throughput

0.282

High

781337

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.265

Low

781344

PKH2
Serine/threonine-protein kinase PKH2

1

0

High-throughput

0.261

Low

781330

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.251

Low

781316

RM15
Large ribosomal subunit protein mL57

1

0

High-throughput

0.249

Low

528810

RLA3
Large ribosomal subunit protein P1B

1

0

High-throughput

0.238

Low

781322

HACD
Very-long-chain

1

0

High-throughput

0.238

Low

781345

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025