HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	9344848, 18507841
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1009
+	Hs
		147414 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK1_HUMAN (39-1000): 0: 846: 44.25
+	Hs
		433329 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FAK1_HUMAN (39-1000): 0: 846: 44.25
+	Mm
		193375 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		FAK1_MOUSE (39-1000): 0: 840: 44.15
+	Hs
		111145 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I6L996_HUMAN (407-1000): 3.6e-180: 541: 45.19
+	Hs
		111147 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		I6L996_HUMAN (407-1000): 3.6e-180: 541: 45.19
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		147427 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		433359 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		147371 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		383538 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (288-695): 1.7e-116: 370: 28.71
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (288-695): 1.7e-116: 370: 28.71
+	Hs
		433231 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		SRC_HUMAN (288-695): 5.62e-117: 371: 27.74
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (288-695): 1.7e-116: 370: 28.71
+	Hs
		433229 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGFR1_HUMAN (360-728): 4.75e-110: 362: 29.08
+	Hs
		147391 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FGFR3_HUMAN (351-683): 4.17e-109: 359: 31.39
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (390-679): 4.86e-56: 213: 38.33