Protein: RGS3
Regulator of G-protein signaling 3 (RGP3) (RGS3)

Gene: RGS3
Organism: Homo sapiens
Interactions: 74
UniProt ID: P49796

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

286764

SKAP2
Src kinase-associated phosphoprotein 2

2

8

High-throughput

0.811

High

890684

PDLI7
PDZ and LIM domain protein 7

2

10

High-throughput

0.811

High

715999

GNA11
Guanine nucleotide-binding protein subunit alpha-11

2

20

Small-scale

0.754

High

890673

COR2A
Coronin-2A

3

0

High-throughput

0.715

High

889538

CLK2
Dual specificity protein kinase CLK2

1

3

High-throughput

0.691

High

600270

ZNF24
Zinc finger protein 24

3

10

High-throughput

0.662

High

890645

EFNB1
Ephrin-B1

3

4

High-throughput

0.662

High

890646

REL
Proto-oncogene c-Rel

3

2

High-throughput

0.662

High

890647

CKAP4
Cytoskeleton-associated protein 4

3

2

High-throughput

0.662

High

890653

SEPT2
Septin-2

3

9

High-throughput

0.662

High

890655

EFNB3
Ephrin-B3

3

4

High-throughput

0.662

High

890656

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

3

3

High-throughput

0.662

High

890671

SEPT8
Septin-8

3

9

High-throughput

0.662

High

890680

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

3

5

High-throughput

0.662

High

890690

SEP10
Septin-10

3

7

High-throughput

0.662

High

846004

CACP
Carnitine O-acetyltransferase

3

0

High-throughput

0.634

High

890681

CEP44
Centrosomal protein of 44 kDa

3

0

High-throughput

0.634

High

174427

ZN646
Zinc finger protein 646

2

2

High-throughput

0.628

High

890642

EFNB2
Ephrin-B2

2

4

High-throughput

0.628

High

890669

ZN397
Zinc finger protein 397

2

3

High-throughput

0.628

High

890687

ZN446
Zinc finger protein 446

2

5

High-throughput

0.628

High

890691

CEP72
Centrosomal protein of 72 kDa

2

2

High-throughput

0.628

High

890644

1433Z
14-3-3 protein zeta/delta

3

17

Small-scale

0.624

High

418623

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

20

Small-scale

0.618

High

475923

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

20

Small-scale

0.618

High

890652

KCTD2
BTB/POZ domain-containing protein KCTD2

3

10

High-throughput

0.604

High

890660

KLH24
Kelch-like protein 24

3

3

High-throughput

0.604

High

890662

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

3

1

High-throughput

0.604

High

890666

KCD17
BTB/POZ domain-containing protein KCTD17

3

10

High-throughput

0.604

High

890658

Z324B
Zinc finger protein 324B

2

0

High-throughput

0.602

High

890689

RBAK
RB-associated KRAB zinc finger protein

2

0

High-throughput

0.602

High

180493

PLS1
Phospholipid scramblase 1

2

0

High-throughput

0.601

High

593820

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

2

High-throughput

0.575

High

890667

KLH23
Kelch-like protein 23

2

3

High-throughput

0.574

High

890677

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

2

1

High-throughput

0.574

High

890683

HES4
Transcription factor HES-4

1

0

High-throughput

0.537

High

882410

ARRB1
Beta-arrestin-1

1

2

High-throughput

0.536

High

890648

IRF5
Interferon regulatory factor 5

1

2

High-throughput

0.536

High

890663

ZSC30
Zinc finger and SCAN domain-containing protein 30

1

4

High-throughput

0.536

High

890679

LOXE3
Hydroperoxide isomerase ALOXE3

1

1

High-throughput

0.536

High

890686

SEP11
Septin-11

1

9

High-throughput

0.536

High

601597

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.515

High

729684

1433B
14-3-3 protein beta/alpha

1

17

Small-scale

0.515

High

890651

ZN460
Zinc finger protein 460

1

0

High-throughput

0.513

High

890664

ARI3B
AT-rich interactive domain-containing protein 3B

1

0

High-throughput

0.513

High

890692

ZN629
Zinc finger protein 629

1

0

High-throughput

0.513

High

421728

A4
Amyloid-beta precursor protein

1

16

High-throughput

0.501

High

890668

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.481

High

890670

DEP1B
DEP domain-containing protein 1B

1

3

Small-scale

0.481

High

425379

ISG15
Ubiquitin-like protein ISG15

1

18

Small-scale

0.479

High

612939

EGR1
Early growth response protein 1

1

4

High-throughput

0.479

High

890693

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

890665

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

299112

FLOT1
Flotillin-1

1

1

High-throughput

0.445

High

391588

FRIH
Ferritin heavy chain

1

1

High-throughput

0.445

High

690833

1433T
14-3-3 protein theta

1

17

Small-scale

0.445

High

890649

SEPT6
Septin-6

1

9

High-throughput

0.445

High

890650

FLOT2
Flotillin-2

1

1

High-throughput

0.445

High

890654

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

1

High-throughput

0.445

High

890657

SEPT7
Septin-7

1

9

High-throughput

0.445

High

890675

AJUBA
LIM domain-containing protein ajuba

1

11

High-throughput

0.445

High

890676

FRMD6
FERM domain-containing protein 6

1

8

High-throughput

0.445

High

890688

KCTD5
BTB/POZ domain-containing protein KCTD5

1

10

High-throughput

0.445

High

890694

SEPT3
Neuronal-specific septin-3

1

9

High-throughput

0.445

High

890695

SEPT9
Septin-9

1

9

High-throughput

0.445

High

890643

CANB1
Calcineurin subunit B type 1

1

0

High-throughput

0.426

High

890678

SSBP3
Single-stranded DNA-binding protein 3

1

0

High-throughput

0.426

High

890685

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

0

High-throughput

0.426

High

890682

GORS2
Golgi reassembly-stacking protein 2

3

0

High-throughput

0.350

High

890661

ATG9A
Autophagy-related protein 9A

3

0

High-throughput

0.345

High

890672

K0232
Uncharacterized protein KIAA0232

2

0

High-throughput

0.328

High

70146

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

890674

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.299

High

890659

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025