HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1308
+	Hs
		147390 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		433253 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		147371 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		383538 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		338763 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		147370 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		337789 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		147424 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK2_HUMAN (676-1190): 1.28e-126: 418: 26.79
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Mm
		193375 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		FAK1_MOUSE (703-997): 3.71e-59: 224: 39.19
+	Hs
		147414 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		111145 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I6L996_HUMAN (703-997): 2.55e-60: 222: 39.53
+	Hs
		433329 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		111147 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		I6L996_HUMAN (703-997): 2.55e-60: 222: 39.53
+	Hs
		992596 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Mm
		193373 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		INSR_MOUSE (353-660): 5.51e-32: 138: 19.05
+	Hs
		146667 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		INSR_HUMAN (353-660): 7.21e-32: 138: 19.05
+	Hs
		147373 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		INSR_HUMAN (353-660): 7.21e-32: 138: 19.05
+	Hs
		147378 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IGF1R_HUMAN (333-691): 3.78e-32: 138: 18.11