HitPredict

Interactor 1: Q9VRJ5 (Q9VRJ5)
Charged multivesicular body protein 2b (LD36173p)
Gene: CHMP2B

Interactor 2: CHMP5 (Q9VVI9)
Charged multivesicular body protein 5 (Vacuolar protein-sorting-associated protein 60)
Gene: Vps60

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0005771 - multivesicular body GO:0015031 - protein transport GO:0032509 - endosome transport via multivesicular body sorting pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 212 Dm			1 226
+	At
		1082311 VPS2B_ARATH (4-210): 3.69e-37: 130: 31.96		VP601_ARATH (1-222): 1.27e-41: 142: 40.69
+	Hs
		97297 E9PSI1_HUMAN (2-196): 5.58e-47: 166: 14.15		CHM4B_HUMAN (15-218): 3.53e-25: 100: 23.42
+	Ce
		1166323 Q9U2F6_CAEEL (2-196): 4.23e-40: 138: 30.26		Q18886_CAEEL (2-218): 1.6e-33: 121: 22.94
+	Dm
		1345401 Q9VRJ5_DROME (1-212): 4.67e-43: 145: 100.00		CHM4_DROME (7-222): 1.35e-30: 114: 24.42
+	Dm
		1482281 Q9VRJ5_DROME (1-212): 4.67e-43: 145: 100.00		Q9VN02_DROME (4-219): 4.79e-29: 110: 12.96
+	At
		307751 VPS2C_ARATH (4-210): 6.51e-43: 145: 36.84		VP321_ARATH (1-223): 2.97e-28: 107: 27.35
+	At
		1373936 VPS2C_ARATH (4-210): 6.51e-43: 145: 36.84		VP202_ARATH (1-213): 1.41e-26: 103: 19.01
+	At
		1373941 VPS2C_ARATH (4-210): 6.51e-43: 145: 36.84		VP322_ARATH (1-223): 2.5e-25: 100: 27.11
+	Dm
		1469211 Q9VRJ5_DROME (1-212): 4.67e-43: 145: 100.00		Q9VBI3_DROME (7-208): 7.07e-25: 100: 17.82
+	At
		1299769 VPS2C_ARATH (4-210): 6.51e-43: 145: 36.84		VP201_ARATH (1-202): 3.74e-25: 99.9: 19.71
+	At
		1082317 VPS2A_ARATH (1-203): 5.6e-43: 145: 34.48		VPS2B_ARATH (7-219): 3.83e-25: 99.8: 15.96
+	Sc
		781314 DID4_YEAST (1-197): 3.26e-37: 130: 26.77		DID4_YEAST (7-225): 1.43e-29: 111: 13.84
+	Sc
		781335 DID4_YEAST (1-197): 3.26e-37: 130: 26.77		VPS60_YEAST (1-207): 2.01e-29: 111: 32.30
+	At
		307748 VPS2B_ARATH (4-210): 3.69e-37: 130: 31.96		VP321_ARATH (1-223): 2.97e-28: 107: 27.35
+	Sc
		781336 DID4_YEAST (1-197): 3.26e-37: 130: 26.77		VPS20_YEAST (6-223): 7.56e-27: 104: 19.09
+	At
		1082300 CHM1A_ARATH (14-211): 5.43e-38: 132: 21.21		VPS2B_ARATH (7-219): 3.83e-25: 99.8: 15.96
+	Sc
		781319 DID4_YEAST (1-197): 3.26e-37: 130: 26.77		SNF7_YEAST (3-211): 3.14e-25: 100: 24.53
+	At
		1082294 VPS2B_ARATH (4-210): 3.69e-37: 130: 31.96		VPS2B_ARATH (7-219): 3.83e-25: 99.8: 15.96
+	Sc
		781326 DID4_YEAST (1-197): 3.26e-37: 130: 26.77		YJE9_YEAST (11-150): 4.78e-09: 57.5: 15.13