Protein: LRS4
Monopolin complex subunit LRS4 (Loss of rDNA silencing protein 4)

Gene: LRS4
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: Q04087

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0033551 - monopolin complex
GO:0034503 - protein localization to nucleolar rDNA repeats

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

636080

CSM1
Monopolin complex subunit CSM1

12

0

Small-scale

0.933

High

810726

NET1
Nucleolar protein NET1

3

1

Small-scale

0.640

High

961481

CDC14
Tyrosine-protein phosphatase CDC14

3

0

Small-scale

0.628

High

339826

CDK1
Cyclin-dependent kinase 1

2

0

High-throughput

0.598

High

355999

H2B2
Histone H2B.2

2

1

Small-scale

0.584

High

969461

TOF2
Topoisomerase 1-associated factor 2

2

1

Small-scale

0.584

High

664536

HRR25
Casein kinase I homolog HRR25

2

0

Small-scale

0.569

High

767611

MAM1
Monopolin complex subunit MAM1

2

0

Small-scale

0.559

High

775248

ULP2
Ubiquitin-like-specific protease 2

2

0

Small-scale

0.559

High

775850

DSN1
Kinetochore-associated protein DSN1

2

0

Small-scale

0.559

High

978540

PRR2
Serine/threonine-protein kinase PRR2

1

1

High-throughput

0.536

High

412588

CDC7
Cell division control protein 7

1

1

Small-scale

0.515

High

744982

CHK1
Serine/threonine-protein kinase CHK1

1

0

High-throughput

0.513

High

977625

VHS1
Serine/threonine-protein kinase VHS1

1

0

High-throughput

0.513

High

614795

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

693153

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

0

Small-scale

0.493

High

412864

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

562758

FUS3
Mitogen-activated protein kinase FUS3

1

0

High-throughput

0.480

High

978539

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.480

High

355622

H2B1
Histone H2B.1

1

1

Small-scale

0.479

High

746541

IMB2
Importin subunit beta-2

1

1

Small-scale

0.479

High

702713

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

745522

CND2
Condensin complex subunit 2

1

0

Small-scale

0.460

High

746777

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

858702

UFD1
Ubiquitin fusion degradation protein 1

1

0

Small-scale

0.460

High

356694

H4
Histone H4

1

0

Small-scale

0.458

High

388124

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

392556

H2A2
Histone H2A.2

1

0

Small-scale

0.458

High

429767

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

Small-scale

0.458

High

515084

MCM1
Pheromone receptor transcription factor

1

0

Small-scale

0.458

High

516323

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.458

High

531692

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

Small-scale

0.458

High

539486

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

Small-scale

0.458

High

560788

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

606132

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

634899

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.458

High

636734

CDC48
Cell division control protein 48

1

0

Small-scale

0.458

High

668167

RIF1
Telomere length regulator protein RIF1

1

0

Small-scale

0.458

High

698929

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

733302

SET3
SET domain-containing protein 3

1

0

Small-scale

0.458

High

744907

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

0

Small-scale

0.458

High

755860

LSM12
Protein LSM12

1

0

Small-scale

0.458

High

759441

STM1
Suppressor protein STM1

1

0

Small-scale

0.458

High

774374

NU159
Nucleoporin NUP159

1

0

Small-scale

0.458

High

861290

PBP1
PAB1-binding protein 1

1

0

Small-scale

0.458

High

972628

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.458

High

972898

IMA1
Importin subunit alpha

1

0

Small-scale

0.458

High

978531

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

978534

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

978536

CSM4
Chromosome segregation in meiosis protein 4

1

0

Small-scale

0.458

High

978538

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

366836

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

977352

SRC1
Inner nuclear membrane protein SRC1

6

0

Small-scale

0.378

High

978537

NUR1
Nuclear rim protein 1

4

0

Small-scale

0.362

High

859117

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

446226

MYO1
Myosin-1

1

0

High-throughput

0.251

Low

629770

STE50
Protein STE50

1

0

High-throughput

0.251

Low

763716

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

361019

TBB
Tubulin beta chain

1

0

Small-scale

0.249

Low

474101

AQY1
Aquaporin-1

1

0

Small-scale

0.249

Low

516911

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.249

Low

653851

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

0

Small-scale

0.249

Low

660819

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.249

Low

691665

NUP2
Nucleoporin NUP2

1

0

Small-scale

0.249

Low

692909

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.249

Low

704138

CSE1
Importin alpha re-exporter

1

0

Small-scale

0.249

Low

754103

YHK5
Putative uncharacterized protein YHR045W

1

0

Small-scale

0.249

Low

767602

NU157
Nucleoporin NUP157

1

0

Small-scale

0.249

Low

773745

6P21
6-phosphofructo-2-kinase 1

1

0

Small-scale

0.249

Low

810978

YJE9
Uncharacterized protein YJL049W

1

0

Small-scale

0.249

Low

973902

PEX25
Peroxisomal membrane protein PEX25

1

0

Small-scale

0.249

Low

978532

KU80
ATP-dependent DNA helicase II subunit 2

1

0

Small-scale

0.249

Low

978533

NUP59
Nucleoporin ASM4

1

0

Small-scale

0.249

Low

978535

YET3
Endoplasmic reticulum transmembrane protein 3

1

0

Small-scale

0.249

Low

978541

CEX1
Cytoplasmic export protein 1

1

0

Small-scale

0.249

Low

732179

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024