HitPredict

Interactor 1: Q9W414 (Q9W414)
Regulatory particle triple-A ATPase 4 (EC 5.6.1.5)
Gene: Rpt4

Interactor 2: PSB3 (Q9XYN7)
Proteasome subunit beta type-3 (20S proteasome subunit beta-3)
Gene: Prosbeta3

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome
Common GO terms	GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 397 Dm			1 205
+	Dm
		822118 Q9W414_DROME (1-397): 4.16e-135: 394: 100.00		PSB1_DROME (2-205): 1.17e-77: 234: 27.91
+	Dm
		822036 PRS4_DROME (13-388): 4.31e-132: 387: 42.41		PSB1_DROME (2-205): 1.17e-77: 234: 27.91
+	Dm
		1264769 Q9W414_DROME (1-397): 4.16e-135: 394: 100.00		Q7K148_DROME (8-205): 1.12e-66: 207: 23.74
+	Hs
		701129 PRS4_HUMAN (14-388): 2.39e-132: 388: 42.52		PSB5_HUMAN (8-205): 9e-68: 209: 22.22
+	Hs
		887511 PRS10_HUMAN (11-397): 4.75e-135: 393: 88.89		PSB3_HUMAN (1-205): 8.68e-66: 203: 63.90
+	Dm
		1376950 Q9W414_DROME (1-397): 4.16e-135: 394: 100.00		PSA5_DROME (6-205): 7.07e-65: 201: 14.69
+	Hs
		700603 PRS10_HUMAN (11-397): 4.75e-135: 393: 88.89		PSA5_HUMAN (6-205): 7.93e-65: 201: 12.92
+	Dm
		874969 PRS4_DROME (13-388): 4.31e-132: 387: 42.41		Q7K148_DROME (8-205): 1.12e-66: 207: 23.74
+	Hs
		633655 PRS10_HUMAN (11-397): 4.75e-135: 393: 88.89		PSB1_HUMAN (2-205): 3.5e-64: 199: 24.41
+	Hs
		887509 PRS4_HUMAN (14-388): 2.39e-132: 388: 42.52		PSB3_HUMAN (1-205): 8.68e-66: 203: 63.90
+	Hs
		975488 PRS10_HUMAN (11-397): 4.75e-135: 393: 88.89		PSB7_HUMAN (5-197): 6.47e-63: 198: 16.58
+	Dm
		1486772 Q9W414_DROME (1-397): 4.16e-135: 394: 100.00		Q9VUJ1_DROME (11-196): 1.88e-62: 196: 18.82
+	Hs
		700600 PRS4_HUMAN (14-388): 2.39e-132: 388: 42.52		PSA5_HUMAN (6-205): 7.93e-65: 201: 12.92
+	Dm
		874988 PRS4_DROME (13-388): 4.31e-132: 387: 42.41		PSA5_DROME (6-205): 7.07e-65: 201: 14.69
+	Hs
		633652 PRS4_HUMAN (14-388): 2.39e-132: 388: 42.52		PSB1_HUMAN (2-205): 3.5e-64: 199: 24.41
+	Hs
		968790 PRS4_HUMAN (14-388): 2.39e-132: 388: 42.52		PSB7_HUMAN (5-197): 6.47e-63: 198: 16.58
+	Hs
		700510 PRS10_HUMAN (11-397): 4.75e-135: 393: 88.89		PSB9_HUMAN (6-200): 1.8e-30: 113: 18.46
+	Dm
		47825 Q9W414_DROME (1-397): 4.16e-135: 394: 100.00		A0AQH0_DROME (7-199): 1.02e-29: 111: 18.65
+	Hs
		700508 PRS4_HUMAN (14-388): 2.39e-132: 388: 42.52		PSB9_HUMAN (6-200): 1.8e-30: 113: 18.46
+	Dm
		47754 PRS4_DROME (13-388): 4.31e-132: 387: 42.41		A0AQH0_DROME (7-199): 1.02e-29: 111: 18.65