Protein: PSB3
Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome subunit beta-3) (beta-3) (Proteasome theta chain)

Gene: PSB3, PSMB3
Organism: Homo sapiens
Interactions: 195
UniProt ID: P49720

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

887581

PSB7
Proteasome subunit beta type-7

9

20

Small-scale

0.972

High

701113

PSB5
Proteasome subunit beta type-5

9

18

Small-scale

0.971

High

887495

PSB2
Proteasome subunit beta type-2

7

20

Small-scale

0.967

High

681124

PSA2
Proteasome subunit alpha type-2

6

19

Small-scale

0.955

High

633628

PSB1
Proteasome subunit beta type-1

6

20

Small-scale

0.953

High

887610

POMP
Proteasome maturation protein

6

12

Small-scale

0.949

High

680813

PSA1
Proteasome subunit alpha type-1

5

20

High-throughput

0.922

High

822129

PSB10
Proteasome subunit beta type-10

5

20

Small-scale

0.922

High

165288

PSA7
Proteasome subunit alpha type-7

4

20

Small-scale

0.908

High

700502

PSB9
Proteasome subunit beta type-9

4

20

High-throughput

0.903

High

700849

PSB4
Proteasome subunit beta type-4

4

19

Small-scale

0.897

High

127903

PSD11
26S proteasome non-ATPase regulatory subunit 11

3

20

High-throughput

0.871

High

337457

PSMG1
Proteasome assembly chaperone 1

3

5

High-throughput

0.871

High

778631

PRS7
26S proteasome regulatory subunit 7

3

20

High-throughput

0.871

High

887509

PRS4
26S proteasome regulatory subunit 4

3

20

High-throughput

0.871

High

887510

PRS8
26S proteasome regulatory subunit 8

3

20

High-throughput

0.871

High

887511

PRS10
26S proteasome regulatory subunit 10B

3

20

High-throughput

0.871

High

887518

PSME1
Proteasome activator complex subunit 1

3

20

High-throughput

0.871

High

887530

PSME4
Proteasome activator complex subunit 4

3

11

High-throughput

0.871

High

887584

PSMG3
Proteasome assembly chaperone 3

3

5

Small-scale

0.866

High

700997

PSB6
Proteasome subunit beta type-6

3

18

Small-scale

0.863

High

610265

PRS6A
26S proteasome regulatory subunit 6A

3

20

High-throughput

0.861

High

681595

PSA4
Proteasome subunit alpha type-4

3

20

High-throughput

0.861

High

700580

PSA5
Proteasome subunit alpha type-5

3

20

High-throughput

0.855

High

887506

PSA6
Proteasome subunit alpha type-6

3

20

Small-scale

0.855

High

700443

PSB8
Proteasome subunit beta type-8

3

20

Small-scale

0.843

High

128179

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

20

High-throughput

0.811

High

681296

PSA3
Proteasome subunit alpha type-3

2

20

High-throughput

0.811

High

851267

PRS6B
26S proteasome regulatory subunit 6B

2

20

High-throughput

0.811

High

887508

PSME3
Proteasome activator complex subunit 3

2

20

High-throughput

0.811

High

887543

PSMG4
Proteasome assembly chaperone 4

2

3

High-throughput

0.811

High

887570

PSMA8
Proteasome subunit alpha-type 8

2

20

High-throughput

0.811

High

887573

PSMF1
Proteasome inhibitor PI31 subunit

2

4

High-throughput

0.811

High

887606

PSME2
Proteasome activator complex subunit 2

2

20

High-throughput

0.811

High

887494

PSB3
Proteasome subunit beta type-3

2

19

Small-scale

0.767

High

138017

PSDE
26S proteasome non-ATPase regulatory subunit 14

6

20

Small-scale

0.730

High

887618

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

5

20

Small-scale

0.716

High

887613

FBX7
F-box only protein 7

5

7

Small-scale

0.712

High

887532

PSMD6
26S proteasome non-ATPase regulatory subunit 6

4

20

High-throughput

0.699

High

571901

TRI27
Zinc finger protein RFP

3

2

High-throughput

0.675

High

210890

PSMD3
26S proteasome non-ATPase regulatory subunit 3

3

10

High-throughput

0.675

High

887588

PIP30
PSME3-interacting protein

3

3

High-throughput

0.675

High

887609

PSD13
26S proteasome non-ATPase regulatory subunit 13

3

14

High-throughput

0.675

High

887502

PSMD4
26S proteasome non-ATPase regulatory subunit 4

3

12

High-throughput

0.667

High

887541

AKIR2
Akirin-2

3

10

Small-scale

0.667

High

887582

PSMD1
26S proteasome non-ATPase regulatory subunit 1

3

20

High-throughput

0.667

High

887522

PSMD2
26S proteasome non-ATPase regulatory subunit 2

3

20

High-throughput

0.662

High

887517

UBE3A
Ubiquitin-protein ligase E3A

3

18

Small-scale

0.640

High

874127

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

9

High-throughput

0.628

High

887497

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

20

High-throughput

0.628

High

887575

PSMG2
Proteasome assembly chaperone 2

2

11

High-throughput

0.628

High

887598

OSER1
Oxidative stress-responsive serine-rich protein 1

2

1

High-throughput

0.628

High

887599

RN181
E3 ubiquitin-protein ligase RNF181

2

7

High-throughput

0.628

High

371471

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.611

High

563420

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

High-throughput

0.611

High

140181

SDCB1
Syntenin-1

2

2

High-throughput

0.606

High

887552

Q6IBT1
Proteasome subunit beta

1

20

High-throughput

0.590

High

241084

PRKN
E3 ubiquitin-protein ligase parkin

2

18

Small-scale

0.584

High

887498

PLK1
Serine/threonine-protein kinase PLK1

2

17

Small-scale

0.584

High

114590

H0YKT8
Proteasome subunit beta

1

20

High-throughput

0.575

High

887503

TERA
Transitional endoplasmic reticulum ATPase

1

13

High-throughput

0.575

High

887545

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

887504

ANM2
Protein arginine N-methyltransferase 2

1

1

High-throughput

0.541

High

389156

FINC
Fibronectin

1

4

High-throughput

0.536

High

542387

TOP2A
DNA topoisomerase 2-alpha

1

3

High-throughput

0.536

High

887512

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

16

High-throughput

0.536

High

887514

SKP1
S-phase kinase-associated protein 1

1

9

High-throughput

0.536

High

887520

TRAF2
TNF receptor-associated factor 2

1

9

High-throughput

0.536

High

887523

CUL1
Cullin-1

1

7

High-throughput

0.536

High

887533

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

12

High-throughput

0.536

High

887534

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.536

High

887542

PDZ11
PDZ domain-containing protein 11

1

2

High-throughput

0.536

High

887548

ECM29
Proteasome adapter and scaffold protein ECM29

1

14

High-throughput

0.536

High

887558

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

High-throughput

0.536

High

887568

ARRD4
Arrestin domain-containing protein 4

1

9

High-throughput

0.536

High

887578

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

High-throughput

0.536

High

887583

SLX1
Structure-specific endonuclease subunit SLX1

1

4

High-throughput

0.536

High

887593

AKIR1
Akirin-1

1

10

High-throughput

0.536

High

887605

AMFR
E3 ubiquitin-protein ligase AMFR

1

12

High-throughput

0.536

High

887614

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

7

High-throughput

0.536

High

822530

VHL
von Hippel-Lindau disease tumor suppressor

1

3

High-throughput

0.515

High

887554

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

3

High-throughput

0.515

High

843380

HD
Huntingtin

1

4

High-throughput

0.515

High

97068

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.514

High

591534

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

887531

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

887565

FANCB
Fanconi anemia group B protein

1

0

High-throughput

0.513

High

887611

HPSE
Heparanase

1

0

High-throughput

0.513

High

181979

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

413410

P53
Cellular tumor antigen p53

1

1

Small-scale

0.501

High

339687

KLF8
Krueppel-like factor 8

1

17

High-throughput

0.500

High

887585

KLF16
Krueppel-like factor 16

1

17

High-throughput

0.500

High

887604

KLF15
Krueppel-like factor 15

1

17

High-throughput

0.500

High

887597

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

High-throughput

0.493

High

539664

MBL2
Mannose-binding protein C

1

2

High-throughput

0.489

High

887550

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

2

High-throughput

0.489

High

887616

TGRM1
TOG array regulator of axonemal microtubules protein 1

1

1

High-throughput

0.489

High

170014

AURKA
Aurora kinase A

1

8

High-throughput

0.479

High

227429

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.479

High

259624

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

271984

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

293375

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

315283

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

324645

HEXI1
Protein HEXIM1

1

4

High-throughput

0.479

High

326533

MFN2
Mitofusin-2

1

5

High-throughput

0.479

High

347577

BAG3
BAG family molecular chaperone regulator 3

1

5

High-throughput

0.479

High

379947

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

High-throughput

0.479

High

425375

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

472286

CFAH
Complement factor H

1

1

Small-scale

0.479

High

519841

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

538909

EPB41
Protein 4.1

1

2

High-throughput

0.479

High

588195

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

607549

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

5

High-throughput

0.479

High

694918

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

767688

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

872071

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

887496

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

887499

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

10

High-throughput

0.479

High

887500

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

887501

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

887505

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

887507

ABCE1
ATP-binding cassette sub-family E member 1

1

2

High-throughput

0.479

High

887513

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

887515

H31
Histone H3.1

1

1

High-throughput

0.479

High

887521

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

Small-scale

0.479

High

887524

CUL4A
Cullin-4A

1

7

High-throughput

0.479

High

887525

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.479

High

887526

TRI14
Tripartite motif-containing protein 14

1

9

High-throughput

0.479

High

887527

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

6

High-throughput

0.479

High

887528

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

14

Small-scale

0.479

High

887529

RBM39
RNA-binding protein 39

1

5

High-throughput

0.479

High

887535

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

9

High-throughput

0.479

High

887536

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.479

High

887537

CL16A
Protein CLEC16A

1

4

High-throughput

0.479

High

887538

LARP7
La-related protein 7

1

4

High-throughput

0.479

High

887540

MIDN
Midnolin

1

5

High-throughput

0.479

High

887547

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

887551

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

887553

DESI1
Desumoylating isopeptidase 1

1

4

Small-scale

0.479

High

887555

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

887557

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

11

High-throughput

0.479

High

887560

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

Small-scale

0.479

High

887561

GOLI
E3 ubiquitin-protein ligase RNF130

1

19

High-throughput

0.479

High

887562

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.479

High

887569

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

887574

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

20

High-throughput

0.479

High

887576

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

887577

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

6

Small-scale

0.479

High

887579

CI072
Guanine nucleotide exchange factor C9orf72

1

5

High-throughput

0.479

High

887586

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

5

Small-scale

0.479

High

887589

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

887591

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

887592

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

1

High-throughput

0.479

High

887594

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

4

High-throughput

0.479

High

887596

UBQL4
Ubiquilin-4

1

20

Small-scale

0.479

High

887600

HECW2
E3 ubiquitin-protein ligase HECW2

1

11

High-throughput

0.479

High

887601

TRM7
tRNA

1

2

High-throughput

0.479

High

887602

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

887603

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

887607

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

887608

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

887617

TRAF6
TNF receptor-associated factor 6

1

10

High-throughput

0.479

High

609963

VGFR1
Vascular endothelial growth factor receptor 1

1

0

High-throughput

0.458

High

659406

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

887559

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

887590

SHRPN
Sharpin

1

0

Small-scale

0.458

High

887595

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

887612

DTX4
E3 ubiquitin-protein ligase DTX4

1

0

Small-scale

0.458

High

887615

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

429525

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

529342

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

887519

NPT2A
Sodium-dependent phosphate transport protein 2A

1

2

High-throughput

0.445

High

105571

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

254558

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.437

High

353106

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

887549

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

887564

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.437

High

887571

DPTOR
DEP domain-containing mTOR-interacting protein

1

2

Small-scale

0.437

High

887572

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

887619

INSI2
Insulin-induced gene 2 protein

1

2

Small-scale

0.437

High

886631

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

693

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.407

High

887539

SL9C1
Solute carrier family 9 member C1

1

3

High-throughput

0.407

High

887544

TMM31
Transmembrane protein 31

1

6

High-throughput

0.407

High

887546

SL9C2
Sodium/hydrogen exchanger 11

1

3

High-throughput

0.407

High

887556

NIPA1
Magnesium transporter NIPA1

1

4

High-throughput

0.407

High

887566

MOT11
Monocarboxylate transporter 11

1

6

High-throughput

0.407

High

887567

CTL5
Choline transporter-like protein 5

1

10

High-throughput

0.407

High

887580

S26A8
Testis anion transporter 1

1

3

High-throughput

0.407

High

887587

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

1

High-throughput

0.407

High

887563

EFC4A
EF-hand calcium-binding domain-containing protein 4A

2

0

High-throughput

0.316

High

669809

MYP0
Myelin protein P0

1

0

High-throughput

0.282

High

887516

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

377191

SOMA
Somatotropin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025