Protein: PSB5
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5)

Gene: PSB5, PSMB5
Organism: Homo sapiens
Interactions: 217
UniProt ID: P28074

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004175 - endopeptidase activity
GO:0004298 - threonine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

633607

PSB1
Proteasome subunit beta type-1

9

20

Small-scale

0.973

High

701113

PSB3
Proteasome subunit beta type-3

9

18

Small-scale

0.971

High

681110

PSA2
Proteasome subunit alpha type-2

8

20

Small-scale

0.966

High

701209

PSB7
Proteasome subunit beta type-7

7

18

Small-scale

0.963

High

701247

POMP
Proteasome maturation protein

6

15

Small-scale

0.949

High

700497

PSB9
Proteasome subunit beta type-9

5

20

Small-scale

0.927

High

701114

PSB2
Proteasome subunit beta type-2

5

19

Small-scale

0.919

High

700837

PSB4
Proteasome subunit beta type-4

4

19

Small-scale

0.902

High

680781

PSA1
Proteasome subunit alpha type-1

4

20

Small-scale

0.897

High

701152

PSME4
Proteasome activator complex subunit 4

3

12

Small-scale

0.861

High

700559

PSA5
Proteasome subunit alpha type-5

3

20

High-throughput

0.855

High

701110

PRS6B
26S proteasome regulatory subunit 6B

3

20

Small-scale

0.847

High

701129

PRS4
26S proteasome regulatory subunit 4

2

20

Small-scale

0.789

High

701130

PRS8
26S proteasome regulatory subunit 8

2

20

Small-scale

0.789

High

681262

PSA3
Proteasome subunit alpha type-3

2

20

Small-scale

0.768

High

700987

PSB6
Proteasome subunit beta type-6

2

18

Small-scale

0.757

High

610237

PRS6A
26S proteasome regulatory subunit 6A

2

20

Small-scale

0.754

High

681579

PSA4
Proteasome subunit alpha type-4

2

20

Small-scale

0.754

High

701105

PRS7
26S proteasome regulatory subunit 7

2

20

Small-scale

0.737

High

701253

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

5

20

Small-scale

0.718

High

137977

PSDE
26S proteasome non-ATPase regulatory subunit 14

5

20

Small-scale

0.702

High

701127

PSA6
Proteasome subunit alpha type-6

1

20

Small-scale

0.699

High

127888

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

20

High-throughput

0.691

High

128158

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

20

High-throughput

0.691

High

165270

PSA7
Proteasome subunit alpha type-7

1

20

High-throughput

0.691

High

700435

PSB8
Proteasome subunit beta type-8

1

19

High-throughput

0.691

High

701139

PSME1
Proteasome activator complex subunit 1

1

20

High-throughput

0.691

High

701121

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

4

11

Small-scale

0.686

High

178001

LSM1
U6 snRNA-associated Sm-like protein LSm1

3

2

High-throughput

0.661

High

701124

PSMD4
26S proteasome non-ATPase regulatory subunit 4

3

13

Small-scale

0.656

High

701143

PSMD2
26S proteasome non-ATPase regulatory subunit 2

3

20

Small-scale

0.656

High

701216

PSMG3
Proteasome assembly chaperone 3

1

5

Small-scale

0.647

High

701138

UBE3A
Ubiquitin-protein ligase E3A

3

19

Small-scale

0.640

High

701153

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

20

High-throughput

0.621

High

701252

TRAF6
TNF receptor-associated factor 6

2

5

High-throughput

0.612

High

371233

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.611

High

336627

BAG4
BAG family molecular chaperone regulator 4

2

3

High-throughput

0.606

High

701170

DUS29
Dual specificity phosphatase 29

2

2

High-throughput

0.606

High

701217

TCHP
Trichoplein keratin filament-binding protein

2

1

High-throughput

0.606

High

701255

NEMO
NF-kappa-B essential modulator

2

2

High-throughput

0.606

High

529147

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.601

High

240822

PRKN
E3 ubiquitin-protein ligase parkin

2

18

Small-scale

0.584

High

701108

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

701156

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

9

Small-scale

0.584

High

701168

DDI2
Protein DDI1 homolog 2

2

20

Small-scale

0.584

High

701219

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

2

Small-scale

0.584

High

701201

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

2

0

High-throughput

0.580

High

701206

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

114586

H0YKT8
Proteasome subunit beta

1

20

High-throughput

0.575

High

701125

TERA
Transitional endoplasmic reticulum ATPase

1

11

High-throughput

0.575

High

213353

ARHG9
Rho guanine nucleotide exchange factor 9

2

2

High-throughput

0.571

High

701166

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

High-throughput

0.571

High

701194

CC150
Coiled-coil domain-containing protein 150

2

2

High-throughput

0.553

High

210868

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

10

High-throughput

0.536

High

251711

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

8

High-throughput

0.536

High

389063

FINC
Fibronectin

1

2

High-throughput

0.536

High

468097

HS90B
Heat shock protein HSP 90-beta

1

7

Small-scale

0.536

High

563249

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.536

High

701116

PSN1
Presenilin-1

1

3

High-throughput

0.536

High

701132

SKP1
S-phase kinase-associated protein 1

1

7

High-throughput

0.536

High

701133

CDKL1
Cyclin-dependent kinase-like 1

1

6

High-throughput

0.536

High

701147

CUL1
Cullin-1

1

6

High-throughput

0.536

High

701155

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

12

High-throughput

0.536

High

701169

ECM29
Proteasome adapter and scaffold protein ECM29

1

14

High-throughput

0.536

High

701189

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

6

High-throughput

0.536

High

701193

ARRD4
Arrestin domain-containing protein 4

1

7

High-throughput

0.536

High

701195

ARRD2
Arrestin domain-containing protein 2

1

7

High-throughput

0.536

High

701204

PSMG2
Proteasome assembly chaperone 2

1

12

High-throughput

0.536

High

701215

SLX1
Structure-specific endonuclease subunit SLX1

1

3

High-throughput

0.536

High

701227

TXNIP
Thioredoxin-interacting protein

1

7

High-throughput

0.536

High

701242

AMFR
E3 ubiquitin-protein ligase AMFR

1

12

High-throughput

0.536

High

701245

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

14

High-throughput

0.536

High

701250

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

6

High-throughput

0.536

High

701254

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

701224

ADT4
ADP/ATP translocase 4

1

2

High-throughput

0.515

High

97065

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.514

High

144166

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

6

Small-scale

0.501

High

181976

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

339664

KLF8
Krueppel-like factor 8

1

17

High-throughput

0.500

High

540816

ERG
Transcriptional regulator ERG

1

2

High-throughput

0.500

High

701211

FEV
Protein FEV

1

2

High-throughput

0.500

High

701213

ELF4
ETS-related transcription factor Elf-4

1

2

High-throughput

0.500

High

701218

KLF16
Krueppel-like factor 16

1

17

High-throughput

0.500

High

327552

ELP1
Elongator complex protein 1

1

0

Small-scale

0.493

High

143568

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

6

High-throughput

0.479

High

169963

AURKA
Aurora kinase A

1

6

High-throughput

0.479

High

186510

TRI18
E3 ubiquitin-protein ligase Midline-1

1

17

Small-scale

0.479

High

214389

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

259487

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

271922

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.479

High

293248

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

315157

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

324566

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

326522

MFN2
Mitofusin-2

1

4

High-throughput

0.479

High

347542

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.479

High

420378

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

425334

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

461175

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

486985

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

507562

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.479

High

519766

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

536559

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

538882

EPB41
Protein 4.1

1

1

High-throughput

0.479

High

542344

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.479

High

587976

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

607533

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

5

High-throughput

0.479

High

635494

NEBU
Nebulin

1

1

High-throughput

0.479

High

694686

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

701103

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.479

High

701104

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

701106

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

701107

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

701111

MAP1B
Microtubule-associated protein 1B

1

5

High-throughput

0.479

High

701112

YAP1
Transcriptional coactivator YAP1

1

14

Small-scale

0.479

High

701115

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

701118

PLK1
Serine/threonine-protein kinase PLK1

1

14

Small-scale

0.479

High

701119

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

701120

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

701122

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

701123

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

701126

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

3

High-throughput

0.479

High

701128

UBC12
NEDD8-conjugating enzyme Ubc12

1

11

High-throughput

0.479

High

701131

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.479

High

701134

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

11

High-throughput

0.479

High

701135

TOP2B
DNA topoisomerase 2-beta

1

2

Small-scale

0.479

High

701141

NFX1
Transcriptional repressor NF-X1

1

7

High-throughput

0.479

High

701142

DUS4
Dual specificity protein phosphatase 4

1

1

High-throughput

0.479

High

701144

ERCC8
DNA excision repair protein ERCC-8

1

6

Small-scale

0.479

High

701145

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

701146

SQSTM
Sequestosome-1

1

5

Small-scale

0.479

High

701149

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.479

High

701150

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

10

Small-scale

0.479

High

701154

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

701157

TBR1
T-box brain protein 1

1

2

High-throughput

0.479

High

701159

PKHN1
Pleckstrin homology domain-containing family N member 1

1

1

Small-scale

0.479

High

701160

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

701162

MIDN
Midnolin

1

5

High-throughput

0.479

High

701163

AKIR2
Akirin-2

1

10

Small-scale

0.479

High

701164

ZMAT1
Zinc finger matrin-type protein 1

1

2

High-throughput

0.479

High

701171

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

701172

DESI1
Desumoylating isopeptidase 1

1

4

Small-scale

0.479

High

701173

CEP85
Centrosomal protein of 85 kDa

1

4

High-throughput

0.479

High

701176

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

701177

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.479

High

701178

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.479

High

701180

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

701182

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

Small-scale

0.479

High

701183

GOLI
E3 ubiquitin-protein ligase RNF130

1

16

High-throughput

0.479

High

701184

MIB1
E3 ubiquitin-protein ligase MIB1

1

1

High-throughput

0.479

High

701187

CDK20
Cyclin-dependent kinase 20

1

5

High-throughput

0.479

High

701190

RN149
E3 ubiquitin-protein ligase RNF149

1

16

High-throughput

0.479

High

701196

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

1

High-throughput

0.479

High

701200

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.479

High

701202

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

701207

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

6

Small-scale

0.479

High

701208

CI072
Guanine nucleotide exchange factor C9orf72

1

5

High-throughput

0.479

High

701210

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.479

High

701212

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.479

High

701214

BAG1
BAG family molecular chaperone regulator 1

1

2

High-throughput

0.479

High

701220

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

7

Small-scale

0.479

High

701221

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

10

High-throughput

0.479

High

701223

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.479

High

701226

ATG5
Autophagy protein 5

1

3

Small-scale

0.479

High

701229

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

701230

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

3

High-throughput

0.479

High

701232

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

701233

ANLN
Anillin

1

1

High-throughput

0.479

High

701234

UBQL4
Ubiquilin-4

1

20

Small-scale

0.479

High

701235

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

701237

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

701239

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

701240

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

701241

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

13

Small-scale

0.479

High

701243

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

701244

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

701246

HDAC5
Histone deacetylase 5

1

3

High-throughput

0.479

High

701248

NINL
Ninein-like protein

1

4

High-throughput

0.479

High

701249

FBX7
F-box only protein 7

1

7

High-throughput

0.479

High

701251

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

701186

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

227386

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

541843

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

701109

MAGA3
Melanoma-associated antigen 3

1

0

Small-scale

0.458

High

701117

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

701136

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.458

High

701137

ERCC6
DNA excision repair protein ERCC-6

1

0

Small-scale

0.458

High

701148

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

High-throughput

0.458

High

701158

FSCN1
Fascin

1

0

High-throughput

0.458

High

701199

RND1
Rho-related GTP-binding protein Rho6

1

0

Small-scale

0.458

High

701205

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

701238

TRM7
tRNA

1

0

High-throughput

0.458

High

429354

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

701140

NPT2A
Sodium-dependent phosphate transport protein 2A

1

1

High-throughput

0.445

High

701181

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

18

High-throughput

0.445

High

701185

CTL2
Choline transporter-like protein 2

1

9

High-throughput

0.445

High

701198

CTL1
Choline transporter-like protein 1

1

9

High-throughput

0.445

High

701225

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

701228

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.445

High

105393

APRIO
Alternative prion protein

1

2

Small-scale

0.439

High

510104

GG12I
G antigen 12I

1

1

High-throughput

0.439

High

701161

GAG2E
G antigen 2E

1

1

High-throughput

0.439

High

353002

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

701151

GRM2
Metabotropic glutamate receptor 2

1

5

High-throughput

0.437

High

701197

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

701231

LFG4
Protein lifeguard 4

1

1

High-throughput

0.437

High

701236

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.437

High

701167

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

Small-scale

0.426

High

690

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.407

High

701165

TMM31
Transmembrane protein 31

1

7

High-throughput

0.407

High

701175

ZNT10
Calcium/manganese antiporter SLC30A10

1

2

High-throughput

0.407

High

701179

NIPA1
Magnesium transporter NIPA1

1

4

High-throughput

0.407

High

701188

CTL3
Choline transporter-like protein 3

1

9

High-throughput

0.407

High

701191

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

701192

CTL5
Choline transporter-like protein 5

1

9

High-throughput

0.407

High

701174

S27A1
Long-chain fatty acid transport protein 1

1

0

High-throughput

0.232

Low

701203

S35B4
Nucleotide sugar transporter SLC35B4

1

0

High-throughput

0.232

Low

701222

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025