Protein: PSB6
Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)

Gene: PSB6, PSMB6
Organism: Homo sapiens
Interactions: 157
UniProt ID: P28072

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004175 - endopeptidase activity
GO:0004298 - threonine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

656637

PSB7
Proteasome subunit beta type-7

6

16

Small-scale

0.949

High

637633

PSA2
Proteasome subunit alpha type-2

5

20

Small-scale

0.934

High

656570

PSB2
Proteasome subunit beta type-2

5

19

Small-scale

0.919

High

594457

PSB1
Proteasome subunit beta type-1

3

20

High-throughput

0.871

High

656569

PSB3
Proteasome subunit beta type-3

3

18

Small-scale

0.863

High

656662

POMP
Proteasome maturation protein

3

14

Small-scale

0.863

High

656416

PSB4
Proteasome subunit beta type-4

3

20

High-throughput

0.861

High

156232

PSA7
Proteasome subunit alpha type-7

3

20

Small-scale

0.855

High

656037

PSB8
Proteasome subunit beta type-8

3

18

Small-scale

0.849

High

656151

PSA5
Proteasome subunit alpha type-5

2

20

High-throughput

0.811

High

656580

PSA6
Proteasome subunit alpha type-6

2

20

Small-scale

0.793

High

637327

PSA1
Proteasome subunit alpha type-1

2

20

High-throughput

0.789

High

656092

PSB9
Proteasome subunit beta type-9

2

20

Small-scale

0.789

High

656591

PSME1
Proteasome activator complex subunit 1

2

20

Small-scale

0.789

High

656559

PSB5
Proteasome subunit beta type-5

2

16

Small-scale

0.757

High

638069

PSA4
Proteasome subunit alpha type-4

2

20

Small-scale

0.754

High

656667

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

4

17

Small-scale

0.697

High

121691

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

20

High-throughput

0.691

High

656563

PRS7
26S proteasome regulatory subunit 7

1

20

High-throughput

0.691

High

656567

PRS6B
26S proteasome regulatory subunit 6B

1

20

High-throughput

0.691

High

656582

PRS4
26S proteasome regulatory subunit 4

1

20

High-throughput

0.691

High

656583

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.691

High

656600

PSME4
Proteasome activator complex subunit 4

1

12

High-throughput

0.691

High

130756

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

20

Small-scale

0.676

High

656590

UBE3A
Ubiquitin-protein ligase E3A

3

16

Small-scale

0.640

High

656629

PSMA8
Proteasome subunit alpha-type 8

1

20

Small-scale

0.621

High

572865

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.618

High

656564

PSB10
Proteasome subunit beta type-10

1

16

Small-scale

0.618

High

656579

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.618

High

656659

PSME2
Proteasome activator complex subunit 2

1

20

Small-scale

0.618

High

656605

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

High-throughput

0.614

High

656578

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

14

High-throughput

0.611

High

656654

NDOR1
NADPH-dependent diflavin oxidoreductase 1

2

4

High-throughput

0.606

High

581459

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

226592

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.584

High

656565

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

656575

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

11

Small-scale

0.584

High

656663

FBX7
F-box only protein 7

2

6

Small-scale

0.584

High

92606

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.575

High

108928

H0YKT8
Proteasome subunit beta

1

20

High-throughput

0.575

High

656596

ARHG7
Rho guanine nucleotide exchange factor 7

2

2

High-throughput

0.571

High

656611

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

656632

ESR2
Estrogen receptor beta

2

5

High-throughput

0.571

High

656572

CAV2
Caveolin-2

2

0

High-throughput

0.547

High

656615

RHGBA
Rho GTPase-activating protein 11A

2

0

High-throughput

0.547

High

121944

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

20

High-throughput

0.536

High

198552

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

11

High-throughput

0.536

High

314738

PSMG1
Proteasome assembly chaperone 1

1

5

High-throughput

0.536

High

336374

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

528600

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.536

High

656585

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

16

High-throughput

0.536

High

656586

SKP1
S-phase kinase-associated protein 1

1

8

High-throughput

0.536

High

656593

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

20

High-throughput

0.536

High

656594

CUL1
Cullin-1

1

6

High-throughput

0.536

High

656601

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

20

High-throughput

0.536

High

656602

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

11

High-throughput

0.536

High

656604

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.536

High

656622

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

19

High-throughput

0.536

High

656625

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

8

High-throughput

0.536

High

656658

AMFR
E3 ubiquitin-protein ligase AMFR

1

12

High-throughput

0.536

High

656661

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

15

High-throughput

0.536

High

656664

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

8

High-throughput

0.536

High

656588

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.515

High

656566

HD
Huntingtin

1

5

High-throughput

0.515

High

171481

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

358716

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.501

High

316800

KLF8
Krueppel-like factor 8

1

17

High-throughput

0.500

High

656641

KLF16
Krueppel-like factor 16

1

17

High-throughput

0.500

High

656656

KLF15
Krueppel-like factor 15

1

17

High-throughput

0.500

High

656603

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

656657

ERRFI
ERBB receptor feedback inhibitor 1

1

2

Small-scale

0.481

High

122510

MEN1
Menin

1

2

High-throughput

0.479

High

175644

TRI18
E3 ubiquitin-protein ligase Midline-1

1

15

Small-scale

0.479

High

243976

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

255530

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.479

High

294405

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

302939

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

304791

MFN2
Mitofusin-2

1

4

High-throughput

0.479

High

345995

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

354306

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

373726

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

397799

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

475370

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.479

High

503492

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

530445

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

625135

CDK2
Cyclin-dependent kinase 2

1

6

High-throughput

0.479

High

650431

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

656561

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

656568

MAP1B
Microtubule-associated protein 1B

1

5

High-throughput

0.479

High

656571

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

656573

PLK1
Serine/threonine-protein kinase PLK1

1

15

Small-scale

0.479

High

656574

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

656576

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

656577

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

656581

UBC12
NEDD8-conjugating enzyme Ubc12

1

11

High-throughput

0.479

High

656584

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

12

High-throughput

0.479

High

656587

VIGLN
Vigilin

1

1

High-throughput

0.479

High

656589

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

7

High-throughput

0.479

High

656592

NFX1
Transcriptional repressor NF-X1

1

5

High-throughput

0.479

High

656595

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.479

High

656597

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

656599

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

656606

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

9

High-throughput

0.479

High

656607

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

656608

LARP7
La-related protein 7

1

4

High-throughput

0.479

High

656609

MIDN
Midnolin

1

5

High-throughput

0.479

High

656610

AKIR2
Akirin-2

1

9

Small-scale

0.479

High

656612

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

656613

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

656616

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

656618

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

656619

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.479

High

656623

GOLI
E3 ubiquitin-protein ligase RNF130

1

17

High-throughput

0.479

High

656624

FBXW8
F-box/WD repeat-containing protein 8

1

2

High-throughput

0.479

High

656626

NHLC2
NHL repeat-containing protein 2

1

3

High-throughput

0.479

High

656627

RN149
E3 ubiquitin-protein ligase RNF149

1

17

High-throughput

0.479

High

656631

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

17

High-throughput

0.479

High

656633

CSN5
COP9 signalosome complex subunit 5

1

20

High-throughput

0.479

High

656634

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.479

High

656635

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.479

High

656636

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

6

Small-scale

0.479

High

656638

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.479

High

656639

BAG1
BAG family molecular chaperone regulator 1

1

2

High-throughput

0.479

High

656640

DERL1
Derlin-1

1

1

Small-scale

0.479

High

656642

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

10

High-throughput

0.479

High

656643

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

656645

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

656646

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

656647

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

4

High-throughput

0.479

High

656648

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

656651

PD1L1
Programmed cell death 1 ligand 1

1

3

High-throughput

0.479

High

656652

DUX4
Double homeobox protein 4

1

5

High-throughput

0.479

High

656653

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

656655

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

656660

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

656665

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

656666

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

386149

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

441704

CFAH
Complement factor H

1

0

Small-scale

0.458

High

521740

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

656560

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

656614

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

656620

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

445826

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

3

High-throughput

0.457

High

690

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.445

High

401468

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

496368

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

656562

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

329394

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

656598

GRM2
Metabotropic glutamate receptor 2

1

4

High-throughput

0.437

High

656617

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

656630

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

656644

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

656649

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

5

High-throughput

0.437

High

656650

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

656628

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

656621

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024