HitPredict

Interactor 1: GOSR2 (O14653)
Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)
Gene: GOSR2

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~V-SNARE_C
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0006906 - vesicle fusion GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Hs			1 236
+	At
		1276968 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP61_ARATH (2-235): 1.3e-61: 195: 20.75
+	Hs
		151533 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		235202 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	At
		1351880 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP51_ARATH (2-235): 7.82e-53: 172: 23.50
+	Hs
		1137468 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		Q5U8S2_HUMAN (3-212): 1.44e-48: 161: 17.65
+	Mm
		292716 VTI1A_MOUSE (2-211): 6.63e-55: 176: 12.38		STX6_MOUSE (3-221): 2.4e-45: 153: 17.72
+	Hs
		1284305 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	Rn
		1144364 VTI1A_RAT (2-211): 8.36e-52: 168: 12.09		STX6_RAT (3-222): 3.2e-46: 155: 17.65
+	Dm
		1373154 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		212966 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Mm
		1265170 Q91XH6_MOUSE (2-210): 9.41e-50: 163: 14.88		STX6_MOUSE (3-221): 2.4e-45: 153: 17.72
+	Rn
		192341 GOSR2_RAT (1-212): 1.8e-63: 197: 91.04		BET1_RAT (149-234): 6.68e-26: 99.1: 22.09
+	Dm
		1374682 Q9W0N6_DROME (1-212): 7.2e-45: 150: 17.89		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		213046 VTI1B_HUMAN (2-190): 7.6e-44: 148: 14.36		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		151530 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Hs
		320379 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		169570 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Hs
		169655 VTI1B_HUMAN (2-190): 7.6e-44: 148: 14.36		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Dm
		1373155 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00
+	Dm
		1374916 Q9W0N6_DROME (1-212): 7.2e-45: 150: 17.89		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00