HitPredict

Interactor 1: TERT (O14746)
Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)
Gene: TERT

Interactor 2: EST1A (Q86US8)
Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a)
Gene: SMG6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 0.60 0.624

The method score is based on:

Property Details
Experiments 12699629, 22011238
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000781 - chromosome, telomeric region
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005697 - telomerase holoenzyme complex
GO:0005730 - nucleolus
and 4 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 1132
Hs

1 1419
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024