HitPredict

Interactor 1: MAD2 (P40958)
Mitotic spindle checkpoint component MAD2 (Mitotic MAD2 protein)
Gene: MAD2

Interactor 2: BUB1 (P41695)
Spindle assembly checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (Checkpoint serine/threonine-protein kinase BUB1)
Gene: BUB1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	24402315, 27618268, 39079532
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0007094 - mitotic spindle assembly checkpoint signaling
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 196 Sc			1 1021
+	Hs
		251750 MD2L1_HUMAN (3-195): 3.26e-86: 254: 42.78		BUB1B_HUMAN (23-1012): 4.2e-130: 422: 15.58
+	Sp
		154036 MAD2_SCHPO (4-195): 1.74e-81: 242: 48.45		BUB1_SCHPO (20-989): 2.33e-122: 401: 24.11
+	Hs
		224113 MD2L1_HUMAN (3-195): 3.26e-86: 254: 42.78		BUB1_HUMAN (178-1016): 7.26e-101: 343: 17.22
+	Sc
		829801 MAD2_YEAST (1-196): 3.27e-88: 259: 100.00		MAD3_YEAST (21-464): 2.2e-102: 332: 29.08
+	Dm
		51957 Q9VRQ2_DROME (5-195): 3.59e-83: 246: 35.71		A1Z6I7_DROME (23-695): 8.17e-87: 308: 14.59
+	Sp
		154033 MAD2_SCHPO (4-195): 1.74e-81: 242: 48.45		MAD3_SCHPO (36-280): 1.57e-58: 205: 20.77
+	At
		199306 MAD2_ARATH (5-195): 1.87e-86: 255: 42.19		BUBR1_ARATH (24-308): 1.45e-26: 115: 17.30
+	Ce
		111812 Q9NGT3_CAEEL (4-195): 4.37e-81: 241: 40.21		G5EDL3_CAEEL (703-926): 5.26e-16: 82.3: 19.48