Protein: BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (Checkpoint serine/threonine-protein kinase BUB1)

Gene: BUB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 41
UniProt ID: P41695

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000779 - condensed chromosome, centromeric region
GO:0000940 - outer kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686917

BUB3
Spindle assembly checkpoint protein BUB3

16

13

Small-scale

0.986

High

835505

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

2

18

Small-scale

0.848

High

826575

DSN1
Kinetochore-associated protein DSN1

5

1

Small-scale

0.703

High

829776

MAD1
Spindle assembly checkpoint component MAD1

3

15

Small-scale

0.674

High

364588

CDK1
Cyclin-dependent kinase 1

1

14

Small-scale

0.647

High

835515

MPS1
Serine/threonine-protein kinase MPS1

1

19

Small-scale

0.647

High

829800

MAD2
Mitotic spindle checkpoint component MAD2

3

8

Small-scale

0.646

High

835508

MAD3
Spindle assembly checkpoint component MAD3

1

11

Small-scale

0.618

High

684627

CDC20
APC/C activator protein CDC20

2

17

Small-scale

0.595

High

835511

MLC1
Myosin light chain 1

1

15

High-throughput

0.595

High

779929

YRA2
RNA annealing protein YRA2

1

0

High-throughput

0.589

High

392888

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.575

High

670828

SIS1
Protein SIS1

1

8

High-throughput

0.575

High

835510

SKP1
Suppressor of kinetochore protein 1

1

2

Small-scale

0.561

High

835517

SGO1
Shugoshin

2

0

Small-scale

0.559

High

623874

MYO2
Myosin-2

1

6

High-throughput

0.515

High

835509

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

7

High-throughput

0.515

High

382158

H4
Histone H4

1

4

Small-scale

0.501

High

439361

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.500

High

592313

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.500

High

597173

BIP
Endoplasmic reticulum chaperone BiP

1

15

High-throughput

0.500

High

805861

ARO9
Aromatic amino acid aminotransferase 2

1

2

High-throughput

0.500

High

835518

VPS5
Vacuolar protein sorting-associated protein 5

1

1

Small-scale

0.494

High

643271

BAS1
Myb-like DNA-binding protein BAS1

1

7

High-throughput

0.481

High

795746

STU1
Protein STU1

1

2

High-throughput

0.481

High

835507

ATG18
Autophagy-related protein 18

1

3

Small-scale

0.479

High

814214

RV167
Reduced viability upon starvation protein 167

1

8

High-throughput

0.470

High

835512

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

Small-scale

0.458

High

792837

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.457

High

835516

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.457

High

367769

ENO1
Enolase 1

1

5

High-throughput

0.457

High

555103

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

524249

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.445

High

526938

HSP72
Heat shock protein SSA2

1

18

High-throughput

0.445

High

545229

SSB1
Ribosome-associated molecular chaperone SSB1

1

20

High-throughput

0.445

High

816254

HSP7E
Heat shock protein SSC3, mitochondrial

1

18

High-throughput

0.445

High

835506

RGD2
Rho-GTPase-activating protein RGD2

1

6

High-throughput

0.439

High

835513

DAM1
DASH complex subunit DAM1

1

2

Small-scale

0.437

High

835514

IST1
Vacuolar protein sorting-associated protein IST1

1

0

High-throughput

0.279

Low

569533

HAP4
Transcriptional activator HAP4

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025