HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.887

Property	Details
Experiments	25402006, 24658140, 22973453, unassigned2173
Identification Methods	two hybrid, protein complementation assay, pull down, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 1210
+	Hs
		156042 SOCS6_HUMAN (1-535): 0: 714: 100.00		ERBB4_HUMAN (1-1208): 0: 1155: 49.12
+	Hs
		155990 SOCS6_HUMAN (1-535): 0: 714: 100.00		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		156003 SOCS6_HUMAN (1-535): 0: 714: 100.00		ERBB3_HUMAN (1-1205): 0: 1102: 41.39
+	Hs
		362630 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		221995 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		473422 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		ERBB4_HUMAN (1-1208): 0: 1155: 49.12
+	Hs
		410540 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		221997 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		473368 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		ERBB3_HUMAN (1-1205): 0: 1102: 41.39
+	Hs
		222017 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		ERBB3_HUMAN (1-1205): 0: 1102: 41.39
+	Hs
		156009 SOCS6_HUMAN (1-535): 0: 714: 100.00		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79
+	Hs
		155991 SOCS6_HUMAN (1-535): 0: 714: 100.00		INSR_HUMAN (336-637): 2.63e-27: 122: 21.64
+	Hs
		222001 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		RET_HUMAN (412-1058): 7.91e-132: 433: 23.02
+	Hs
		222044 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52
+	Hs
		222022 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79
+	Hs
		473406 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		ACK1_HUMAN (691-967): 4.56e-56: 214: 39.58
+	Hs
		473401 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		473378 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		ABL2_HUMAN (707-974): 5.55e-52: 202: 40.37
+	Hs
		222027 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		ABL2_HUMAN (707-974): 5.55e-52: 202: 40.37
+	Dm
		409175 SRC42_DROME (277-502): 2.59e-59: 206: 18.67		EGFR_DROME (30-339): 1e-25: 117: 21.28