HitPredict

Interactor 1: RASM (O14807)
Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
Gene: MRAS

Interactor 2: GNDS (Q12967)
Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)
Gene: RALGDS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	9400994, 10498616
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 208 Hs			1 914
+	Hs
		905420 RRAS2_HUMAN (14-194): 8.41e-64: 197: 60.00		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Hs
		897883 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Hs
		919618 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Dm
		381636 RAS2_DROME (11-191): 1.57e-59: 186: 58.38		Q9U4U5_DROME (65-887): 4.47e-166: 511: 27.40
+	Hs
		156101 RASM_HUMAN (1-208): 1.97e-98: 285: 100.00		RPGF5_HUMAN (53-648): 2.74e-121: 382: 16.18
+	Hs
		919656 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF4_HUMAN (30-650): 4.1e-128: 412: 16.26
+	Hs
		313169 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		RPGF3_HUMAN (30-680): 3e-125: 403: 15.69
+	Hs
		313171 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF3_HUMAN (30-680): 3e-125: 403: 15.69
+	Hs
		156099 RASM_HUMAN (1-208): 1.97e-98: 285: 100.00		RPGF6_HUMAN (322-772): 3.38e-80: 286: 15.86
+	Hs
		919657 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF5_HUMAN (53-648): 2.74e-121: 382: 16.18
+	Ce
		1089983 RAP1_CAEEL (11-208): 2.42e-85: 251: 46.47		Q19770_CAEEL (237-817): 2.5e-92: 307: 12.11
+	Hs
		919645 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RGDSR_HUMAN (176-650): 3.89e-111: 351: 40.84
+	Hs
		919653 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF6_HUMAN (322-772): 3.38e-80: 286: 15.86
+	Hs
		919625 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF1_HUMAN (370-660): 1.16e-67: 247: 26.71
+	Hs
		905457 RRAS2_HUMAN (14-194): 8.41e-64: 197: 60.00		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00
+	Hs
		897964 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00
+	Hs
		919681 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00
+	Hs
		905428 RRAS2_HUMAN (14-194): 8.41e-64: 197: 60.00		RGL3_HUMAN (62-248): 1.8e-34: 143: 26.84
+	Hs
		171543 RRAS2_HUMAN (14-194): 8.41e-64: 197: 60.00		RGL2_HUMAN (62-253): 1.03e-18: 93.5: 20.20
+	Hs
		171541 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		RGL2_HUMAN (62-253): 1.03e-18: 93.5: 20.20