Protein: P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)

Gene: P55G, PIK3R3
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q92569

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0005829 - cytosol
GO:0005943 - phosphatidylinositol 3-kinase complex, class IA
GO:0006955 - immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839058

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

10

20

Small-scale

0.973

High

839168

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

6

20

Small-scale

0.939

High

132797

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

5

20

High-throughput

0.924

High

136417

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

5

20

High-throughput

0.919

High

363648

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.918

High

1051030

FAK1
Focal adhesion kinase 1

4

20

Small-scale

0.893

High

156060

SOCS6
Suppressor of cytokine signaling 6

4

20

High-throughput

0.885

High

699816

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

20

High-throughput

0.871

High

1060800

ACK1
Activated CDC42 kinase 1

3

20

Small-scale

0.864

High

788976

TGFR2
TGF-beta receptor type-2

3

12

High-throughput

0.861

High

987808

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.858

High

641641

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

20

High-throughput

0.857

High

855709

CRK
Adapter molecule crk

3

20

High-throughput

0.852

High

410972

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

20

High-throughput

0.845

High

557409

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.827

High

473453

HCK
Tyrosine-protein kinase HCK

2

19

High-throughput

0.819

High

1364862

SPSB2
SPRY domain-containing SOCS box protein 2

2

10

High-throughput

0.819

High

1364881

SH22A
SH2 domain-containing protein 2A

2

20

High-throughput

0.819

High

465593

IGF1R
Insulin-like growth factor 1 receptor

2

20

Small-scale

0.806

High

463181

YES
Tyrosine-protein kinase Yes

2

19

High-throughput

0.783

High

902870

BLK
Tyrosine-protein kinase Blk

2

20

High-throughput

0.783

High

907284

STA5B
Signal transducer and activator of transcription 5B

2

20

High-throughput

0.783

High

594065

NCK1
SH2/SH3 adapter protein NCK1

2

20

High-throughput

0.767

High

827867

STAT3
Signal transducer and activator of transcription 3

2

20

High-throughput

0.767

High

840975

ABL2
Tyrosine-protein kinase ABL2

2

19

High-throughput

0.767

High

1054130

BTK
Tyrosine-protein kinase BTK

2

20

High-throughput

0.767

High

1364854

HSH2D
Hematopoietic SH2 domain-containing protein

2

20

High-throughput

0.767

High

710402

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.754

High

440656

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.743

High

597902

FER
Tyrosine-protein kinase Fer

2

19

High-throughput

0.743

High

593458

PGFRA
Platelet-derived growth factor receptor alpha

2

20

High-throughput

0.737

High

1360859

SOCS4
Suppressor of cytokine signaling 4

2

20

High-throughput

0.732

High

1364888

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

4

High-throughput

0.726

High

772510

IRS1
Insulin receptor substrate 1

5

20

Small-scale

0.714

High

532095

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

1364877

DOCK5
Dedicator of cytokinesis protein 5

1

15

High-throughput

0.691

High

1281162

CLNK
Cytokine-dependent hematopoietic cell linker

2

20

High-throughput

0.686

High

1364903

IRS2
Insulin receptor substrate 2

3

20

Small-scale

0.667

High

1328375

CCD33
Coiled-coil domain-containing protein 33

2

3

High-throughput

0.665

High

848052

AL3B1
Aldehyde dehydrogenase family 3 member B1

3

2

High-throughput

0.662

High

1349505

FNDC8
Fibronectin type III domain-containing protein 8

2

0

High-throughput

0.655

High

1364855

CEP19
Centrosomal protein of 19 kDa

4

0

High-throughput

0.654

High

1145758

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1316688

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

412355

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.646

High

651390

CBL
E3 ubiquitin-protein ligase CBL

2

20

High-throughput

0.634

High

1232976

OTU7B
OTU domain-containing protein 7B

2

3

High-throughput

0.634

High

1364858

RET7
Retinoid-binding protein 7

2

1

High-throughput

0.634

High

1364883

PAR6A
Partitioning defective 6 homolog alpha

2

11

High-throughput

0.634

High

160568

IRS4
Insulin receptor substrate 4

2

20

High-throughput

0.628

High

1364887

EHD2
EH domain-containing protein 2

2

8

High-throughput

0.628

High

1364898

NISCH
Nischarin

2

9

High-throughput

0.628

High

239327

MYPT2
Protein phosphatase 1 regulatory subunit 12B

2

17

High-throughput

0.628

High

1316756

WDFY3
WD repeat and FYVE domain-containing protein 3

2

6

High-throughput

0.628

High

1133354

NC2A
Dr1-associated corepressor

4

1

High-throughput

0.623

High

1364853

LMBL3
Lethal(3)malignant brain tumor-like protein 3

4

5

High-throughput

0.623

High

472107

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

463686

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.618

High

648609

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

1034305

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

1159522

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1324344

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

2

0

High-throughput

0.607

High

725427

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

10

High-throughput

0.606

High

1121164

SRTD2
SERTA domain-containing protein 2

2

1

High-throughput

0.606

High

1127361

CASL
Enhancer of filamentation 1

2

20

High-throughput

0.606

High

1195576

ARI4B
AT-rich interactive domain-containing protein 4B

2

7

High-throughput

0.606

High

1218947

TASO2
Protein TASOR 2

2

10

High-throughput

0.606

High

1364884

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.606

High

1106496

GAB1
GRB2-associated-binding protein 1

2

20

High-throughput

0.602

High

843821

HD
Huntingtin

2

7

High-throughput

0.596

High

116831

I6L996
Focal adhesion kinase-related nonkinase

1

20

High-throughput

0.594

High

934928

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.594

High

1040868

MECOM
Histone-lysine N-methyltransferase MECOM

2

4

High-throughput

0.594

High

1364850

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

2

16

High-throughput

0.594

High

540594

LAMP1
Lysosome-associated membrane glycoprotein 1

2

12

High-throughput

0.584

High

252617

TSN2
Tetraspanin-2

2

3

High-throughput

0.584

High

619257

TNNI1
Troponin I, slow skeletal muscle

2

0

High-throughput

0.580

High

1103010

CENPR
Centromere protein R

2

0

High-throughput

0.580

High

1335996

SMIP6
Sperm microtubule inner protein 6

2

0

High-throughput

0.580

High

1364865

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1364893

PLAT4
Phospholipase A and acyltransferase 4

2

0

High-throughput

0.580

High

220286

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.579

High

922366

CRBA2
Beta-crystallin A2

2

2

High-throughput

0.579

High

1120033

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

2

9

High-throughput

0.576

High

1215338

DCAF8
DDB1- and CUL4-associated factor 8

2

3

High-throughput

0.576

High

1364885

MBIP1
MAP3K12-binding inhibitory protein 1

2

1

High-throughput

0.576

High

1364859

WRIP1
ATPase WRNIP1

3

1

High-throughput

0.576

High

484194

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.575

High

1195249

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.574

High

1351513

HAVR2
Hepatitis A virus cellular receptor 2

2

6

High-throughput

0.574

High

1364886

NLGN3
Neuroligin-3

2

2

High-throughput

0.574

High

1347274

OLIG1
Oligodendrocyte transcription factor 1

2

4

High-throughput

0.573

High

414317

P53
Cellular tumor antigen p53

1

8

Small-scale

0.569

High

442772

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.561

High

51471

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

20

High-throughput

0.555

High

70928

CMI2B
Ciliary microtubule inner protein 2B

2

1

High-throughput

0.553

High

302194

NEBL
Nebulette

2

20

High-throughput

0.553

High

1152934

NAB2
NGFI-A-binding protein 2

2

1

High-throughput

0.553

High

1250851

CRDL2
Chordin-like protein 2

2

4

High-throughput

0.553

High

1253070

ZN620
Zinc finger protein 620

2

2

High-throughput

0.553

High

1331738

CCD89
Coiled-coil domain-containing protein 89

2

5

High-throughput

0.553

High

1364861

ZBT18
Zinc finger and BTB domain-containing protein 18

2

5

High-throughput

0.553

High

1364866

SSBP4
Single-stranded DNA-binding protein 4

2

3

High-throughput

0.553

High

1364867

PBX4
Pre-B-cell leukemia transcription factor 4

2

1

High-throughput

0.553

High

1364880

PKHF2
Pleckstrin homology domain-containing family F member 2

2

10

High-throughput

0.553

High

711921

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.553

High

931877

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

387134

TNNC2
Troponin C, skeletal muscle

2

0

High-throughput

0.551

High

1357189

BRK1
Protein BRICK1

2

0

High-throughput

0.551

High

1364860

CRBN
Protein cereblon

2

0

High-throughput

0.551

High

190448

COPT1
High affinity copper uptake protein 1

2

2

High-throughput

0.549

High

282759

E2F6
Transcription factor E2F6

2

2

High-throughput

0.542

High

288479

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

8

High-throughput

0.542

High

1060621

PPARA
Peroxisome proliferator-activated receptor alpha

2

19

High-throughput

0.542

High

1193452

CCD14
Coiled-coil domain-containing protein 14

2

1

High-throughput

0.542

High

1364899

ZN281
Zinc finger protein 281

2

3

High-throughput

0.542

High

1364904

PCDB5
Protocadherin beta-5

2

5

High-throughput

0.542

High

1059906

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

High-throughput

0.541

High

520234

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

532822

CH60
60 kDa heat shock protein, mitochondrial

1

9

High-throughput

0.536

High

1007889

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

720285

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.528

High

1149944

TERF2
Telomeric repeat-binding factor 2

2

2

High-throughput

0.526

High

1204691

ZMAT1
Zinc finger matrin-type protein 1

2

2

High-throughput

0.526

High

1364868

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.526

High

1364892

KLF15
Krueppel-like factor 15

2

9

High-throughput

0.526

High

1364894

KMT2B
Histone-lysine N-methyltransferase 2B

2

13

High-throughput

0.526

High

1364901

MTF2
Metal-response element-binding transcription factor 2

2

2

High-throughput

0.526

High

1364902

ZN451
E3 SUMO-protein ligase ZNF451

2

2

High-throughput

0.526

High

1063000

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.514

High

389632

AMBP
Protein AMBP

1

15

High-throughput

0.508

High

576808

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.508

High

1054625

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.508

High

1055835

RING1
E3 ubiquitin-protein ligase RING1

1

10

High-throughput

0.508

High

1139654

SYK
Lysine--tRNA ligase

1

4

High-throughput

0.508

High

1316040

TRM2A
tRNA

1

2

High-throughput

0.508

High

1352042

MICA1
[F-actin]-monooxygenase MICAL1

1

20

High-throughput

0.508

High

1364870

KLC2
Kinesin light chain 2

1

2

High-throughput

0.508

High

1364882

ABCB6
ATP-binding cassette sub-family B member 6

1

4

High-throughput

0.508

High

976458

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.501

High

630177

ACM3
Muscarinic acetylcholine receptor M3

1

6

High-throughput

0.489

High

868331

V1BR
Vasopressin V1b receptor

1

11

High-throughput

0.489

High

1116830

AVR2B
Activin receptor type-2B

1

12

High-throughput

0.489

High

1161852

AMHR2
Anti-Muellerian hormone type-2 receptor

1

12

High-throughput

0.489

High

1364857

NOE3
Noelin-3

1

2

High-throughput

0.489

High

1364879

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

1364891

I20RA
Interleukin-20 receptor subunit alpha

1

20

High-throughput

0.489

High

1364905

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.489

High

297314

SERF1
Small EDRK-rich factor 1

1

0

High-throughput

0.486

High

390297

VTDB
Vitamin D-binding protein

1

0

High-throughput

0.486

High

868222

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.486

High

963343

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.486

High

1364874

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.486

High

1085599

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.481

High

601391

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

613116

EGR1
Early growth response protein 1

1

7

High-throughput

0.479

High

914460

EFNB2
Ephrin-B2

1

9

High-throughput

0.479

High

962332

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

1145042

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.479

High

1292791

SKAP1
Src kinase-associated phosphoprotein 1

1

20

High-throughput

0.479

High

1364851

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

1

High-throughput

0.479

High

1364873

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.479

High

1364876

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

387863

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.464

High

1260305

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

11

High-throughput

0.464

High

1325743

LNX2
Ligand of Numb protein X 2

1

18

High-throughput

0.464

High

1364900

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.464

High

944016

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.445

High

1364896

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.445

High

959506

YPEL3
Protein yippee-like 3

1

2

High-throughput

0.439

High

71397

HECA2
HEPACAM family member 2

1

20

High-throughput

0.437

High

174577

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.437

High

277388

TP4A3
Protein tyrosine phosphatase type IVA 3

1

14

High-throughput

0.437

High

583975

CD19
B-lymphocyte antigen CD19

1

6

Small-scale

0.437

High

1270277

BT2A1
Butyrophilin subfamily 2 member A1

1

9

High-throughput

0.437

High

1364875

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.437

High

1364897

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

18

High-throughput

0.437

High

1112315

PWP1
Periodic tryptophan protein 1 homolog

1

4

High-throughput

0.417

High

183954

S22A2
Solute carrier family 22 member 2

1

5

High-throughput

0.407

High

876433

EAA4
Excitatory amino acid transporter 4

1

6

High-throughput

0.407

High

1133795

SL9A5
Sodium/hydrogen exchanger 5

1

4

High-throughput

0.407

High

1310907

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

9

High-throughput

0.407

High

1359843

GAB3
GRB2-associated-binding protein 3

1

20

High-throughput

0.407

High

1364869

CHIA
Acidic mammalian chitinase

1

1

High-throughput

0.407

High

1364889

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

1364895

S12A4
Solute carrier family 12 member 4

1

13

High-throughput

0.407

High

1364906

S4A7
Sodium bicarbonate cotransporter 3

1

5

High-throughput

0.407

High

1211247

PKHS1
Pleckstrin homology domain-containing family S member 1

2

0

High-throughput

0.334

High

1226788

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

2

0

High-throughput

0.331

High

1329265

MET27
Methyltransferase-like protein 27

2

0

High-throughput

0.331

High

705834

AMPL
Cytosol aminopeptidase

2

0

High-throughput

0.316

High

1187434

CC036
Uncharacterized protein C3orf36

2

0

High-throughput

0.316

High

1256451

K0408
Uncharacterized protein KIAA0408

2

0

High-throughput

0.316

High

1364856

SPT32
Spermatogenesis-associated protein 32

2

0

High-throughput

0.316

High

1364863

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

2

0

High-throughput

0.316

High

1364871

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1364872

GO45
Golgin-45

2

0

High-throughput

0.316

High

1240630

PLB1
Phospholipase B1, membrane-associated

2

0

High-throughput

0.310

High

1332360

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

0

High-throughput

0.310

High

1364864

PELO
Protein pelota homolog

2

0

High-throughput

0.310

High

1325187

HROB
Homologous recombination OB-fold protein

2

0

High-throughput

0.300

High

1330481

PACRL
PACRG-like protein

2

0

High-throughput

0.300

High

1364878

AUNIP
Aurora kinase A- and ninein-interacting protein

2

0

High-throughput

0.300

High

283712

GPC4
Glypican-4

1

0

High-throughput

0.279

Low

1248415

CP054
Transmembrane protein C16orf54

1

0

High-throughput

0.279

Low

1361123

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.279

Low

4790

A0A1B0GWI1
Coiled-coil domain containing 196

1

0

High-throughput

0.268

Low

389669

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.265

Low

1364890

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.265

Low

1364852

FWCH2
FLYWCH family member 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025