HitPredict

Interactor 1: AP3D1 (O14617)
AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin)
Gene: AP3D1

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24797263
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0010008 - endosome membrane GO:0016020 - membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1153 Hs			1 1210
+	Hs
		225759 AP1G1_HUMAN (17-836): 0: 595: 18.83		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Mm
		205314 AP1B1_MOUSE (37-907): 0: 570: 15.44		EGFR_MOUSE (1-1210): 0: 1267: 90.35
+	Hs
		363105 AP2B1_HUMAN (37-965): 0: 580: 14.83		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		363191 AP1B1_HUMAN (37-965): 0: 578: 15.09		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		295719 AP1G2_HUMAN (18-767): 2.57e-168: 518: 17.16		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		410814 AP3B2_HUMAN (41-1152): 0: 633: 12.59		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Mm
		604455 AP2A1_MOUSE (16-658): 9.22e-150: 475: 20.17		EGFR_MOUSE (1-1210): 0: 1267: 90.35
+	Hs
		323641 AP2A2_HUMAN (16-652): 7.07e-149: 472: 19.68		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		344590 AP2A1_HUMAN (16-729): 3.61e-148: 471: 18.78		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		410758 AP2B1_HUMAN (37-965): 0: 580: 14.83		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		710165 AP2B1_HUMAN (37-965): 0: 580: 14.83		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79
+	Rn
		74719 B2RYN6_RAT (17-836): 0: 598: 18.71		INSR_RAT (579-1032): 3.03e-104: 361: 23.87
+	Rn
		108237 G3V9N8_RAT (37-907): 1.99e-180: 555: 15.32		INSR_RAT (579-1032): 3.03e-104: 361: 23.87
+	Rn
		580496 COPG1_RAT (32-869): 7.12e-172: 531: 12.98		INSR_RAT (579-1032): 3.03e-104: 361: 23.87
+	Hs
		344631 AP2A1_HUMAN (16-729): 3.61e-148: 471: 18.78		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79