HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	16189514, 16159959
Identification Methods	two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	VHS~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0016236 - macroautophagy
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 589
+	Hs
		160220 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		160203 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Hs
		277154 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		277153 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		1173032 TM1L2_HUMAN (5-448): 6.41e-50: 185: 17.17		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		277139 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Hs
		1270627 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		160088 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		UBQLN_HUMAN (33-453): 5.18e-74: 245: 33.48
+	Hs
		272826 TM1L1_HUMAN (5-474): 3.95e-38: 150: 15.19		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		313512 ZFYV9_HUMAN (155-489): 1.2e-38: 157: 20.63		BAG6_HUMAN (25-536): 2.14e-33: 138: 14.66
+	Hs
		277047 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Hs
		924099 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Hs
		924051 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68