HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: PP12C (Q9BZL4)
Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85)
Gene: PPP1R12C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.715

Property	Details
Experiments	28330616
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Ank_2, PRKG1_interact~PRKG1_interact
Common GO terms	GO:0001725 - stress fiber GO:0004857 - enzyme inhibitor activity GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0019208 - phosphatase regulator activity and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1030 Hs			1 782
+	Hs
		1318220 TNKS2_HUMAN (1-611): 2.38e-60: 227: 12.05		PP12C_HUMAN (1-782): 1.36e-154: 471: 100.00
+	Hs
		161473 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		ANR50_HUMAN (65-441): 3.02e-68: 248: 19.15
+	Hs
		161258 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		1294324 PP16A_HUMAN (2-310): 2.43e-80: 273: 36.11		PP16A_HUMAN (13-478): 5.8e-85: 281: 29.56
+	Mm
		970499 ANS1B_MOUSE (44-836): 6.65e-73: 265: 15.88		ANK1_MOUSE (12-662): 6.13e-74: 265: 16.17
+	Hs
		166914 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		ANR28_HUMAN (55-452): 4.36e-66: 240: 19.01
+	Hs
		980449 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		ANR44_HUMAN (51-452): 4.82e-65: 236: 15.93
+	Hs
		883496 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		ANK3_HUMAN (56-476): 1.58e-62: 231: 16.89
+	Hs
		1021462 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		ANK3_HUMAN (56-476): 1.58e-62: 231: 16.89
+	Hs
		167036 ANR50_HUMAN (22-935): 8.69e-65: 241: 13.09		ANR28_HUMAN (55-452): 4.36e-66: 240: 19.01
+	Hs
		167014 TNKS2_HUMAN (1-611): 2.38e-60: 227: 12.05		ANR28_HUMAN (55-452): 4.36e-66: 240: 19.01
+	Hs
		225135 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		225123 ANK1_HUMAN (1-934): 3.93e-69: 255: 12.47		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		883487 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		ANK2_HUMAN (192-510): 1.07e-25: 116: 13.86
+	Hs
		965154 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		ANK2_HUMAN (192-510): 1.07e-25: 116: 13.86
+	Hs
		225160 TNKS2_HUMAN (1-611): 2.38e-60: 227: 12.05		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		883678 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		ANKR6_HUMAN (51-186): 9.28e-19: 93.2: 24.27
+	Hs
		1330891 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		ANKR6_HUMAN (51-186): 9.28e-19: 93.2: 24.27