HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2390 Hs			1 1430
+	Hs
		862027 SPTB2_HUMAN (3-2390): 0: 712: 61.09		DAPK1_HUMAN (1-1430): 0: 1999: 100.00
+	Hs
		211541 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		DAPK1_HUMAN (1-1430): 0: 1999: 100.00
+	Hs
		521508 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		DAPK1_HUMAN (1-1430): 0: 1999: 100.00
+	Hs
		164604 SPTN2_HUMAN (1-2390): 0: 715: 100.00		ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42
+	Hs
		963292 SPTB2_HUMAN (3-2390): 0: 712: 61.09		ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42
+	Mm
		103603 SPTB2_MOUSE (3-2390): 0: 710: 60.96		ANK3_MOUSE (518-936): 2.88e-74: 276: 16.06
+	Hs
		556695 SPTB2_HUMAN (3-2390): 0: 712: 61.09		ANK1_HUMAN (503-915): 9.04e-72: 267: 15.66
+	Mm
		103598 Q3UGX2_MOUSE (5-2339): 0: 670: 51.26		ANK3_MOUSE (518-936): 2.88e-74: 276: 16.06
+	Mm
		57853 SPTB2_MOUSE (3-2390): 0: 710: 60.96		KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91
+	Mm
		57856 Q68FG2_MOUSE (1-2390): 0: 705: 94.85		KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91
+	Hs
		211695 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17
+	Mm
		515254 ACTN2_MOUSE (33-677): 2.05e-118: 401: 38.77		KCC2A_MOUSE (1-383): 5.07e-120: 385: 29.17
+	Hs
		164611 SPTN2_HUMAN (1-2390): 0: 715: 100.00		ANK3_HUMAN (737-962): 6.16e-11: 69.6: 12.16
+	Rn
		88556 D3ZCV0_RAT (56-596): 3.78e-118: 399: 42.45		KCC2A_RAT (1-383): 5.07e-120: 385: 29.17
+	Hs
		963306 SPTB2_HUMAN (3-2390): 0: 712: 61.09		ANK3_HUMAN (737-962): 6.16e-11: 69.6: 12.16
+	Rn
		506781 ACTN1_RAT (31-766): 1.08e-87: 310: 31.88		KCC2A_RAT (1-383): 5.07e-120: 385: 29.17
+	Hs
		521641 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17
+	Hs
		360612 SPTA1_HUMAN (182-1386): 5.78e-93: 340: 19.37		ANK1_HUMAN (503-915): 9.04e-72: 267: 15.66
+	Mm
		57827 SPTN1_MOUSE (279-2273): 1.18e-78: 293: 19.03		KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91
+	Hs
		809108 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		ANK3_HUMAN (737-962): 6.16e-11: 69.6: 12.16