Protein: PVR
Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)

Gene: PVR
Organism: Homo sapiens
Interactions: 164
UniProt ID: P15151

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0002860 - positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

580773

CD226
CD226 antigen

4

17

Small-scale

0.886

High

580780

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

3

3

Small-scale

0.865

High

580793

NT2NA
Notch homolog 2 N-terminal-like protein A

3

20

High-throughput

0.861

High

133164

QSOX1
Sulfhydryl oxidase 1

2

6

High-throughput

0.811

High

501798

CO4A
Complement C4-A

2

1

High-throughput

0.811

High

580755

RAB5B
Ras-related protein Rab-5B

2

12

High-throughput

0.811

High

580781

CDON
Cell adhesion molecule-related/down-regulated by oncogenes

2

13

High-throughput

0.811

High

125203

LEG9
Galectin-9

2

10

High-throughput

0.789

High

580774

ADIPO
Adiponectin

2

4

High-throughput

0.783

High

580797

ANR46
Ankyrin repeat domain-containing protein 46

2

10

High-throughput

0.783

High

580803

CLD19
Claudin-19

2

1

High-throughput

0.783

High

580812

NINJ1
Ninjurin-1

2

1

High-throughput

0.783

High

580821

AQP10
Aquaporin-10

2

1

High-throughput

0.783

High

580847

GPC5D
G-protein coupled receptor family C group 5 member D

2

1

High-throughput

0.783

High

580848

NINJ2
Ninjurin-2

2

1

High-throughput

0.783

High

580839

NECT3
Nectin-3

2

17

Small-scale

0.778

High

580735

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

2

High-throughput

0.776

High

580740

TNFL9
Tumor necrosis factor ligand superfamily member 9

2

0

High-throughput

0.770

High

580826

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

2

0

High-throughput

0.770

High

580857

MTCH2
Mitochondrial carrier homolog 2

2

0

High-throughput

0.770

High

580765

CD47
Leukocyte surface antigen CD47

2

0

High-throughput

0.742

High

580818

S41A2
Solute carrier family 41 member 2

2

0

High-throughput

0.742

High

540299

LAMP1
Lysosome-associated membrane glycoprotein 1

2

3

High-throughput

0.737

High

580741

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

2

5

High-throughput

0.726

High

580767

ATR
Serine/threonine-protein kinase ATR

2

1

High-throughput

0.726

High

580792

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

2

3

High-throughput

0.726

High

580836

WNK1
Serine/threonine-protein kinase WNK1

1

3

High-throughput

0.698

High

580824

ZNT2
Proton-coupled zinc antiporter SLC30A2

4

5

High-throughput

0.698

High

520734

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.691

High

580727

TSHR
Thyrotropin receptor

1

6

High-throughput

0.691

High

580728

LEG3
Galectin-3

1

10

High-throughput

0.691

High

580729

EPHA1
Ephrin type-A receptor 1

1

12

High-throughput

0.691

High

580730

ITA6
Integrin alpha-6

1

2

High-throughput

0.691

High

580746

RAB13
Ras-related protein Rab-13

1

6

High-throughput

0.691

High

580750

CD81
CD81 antigen

1

10

Small-scale

0.691

High

580764

PCDH1
Protocadherin-1

1

9

High-throughput

0.691

High

580766

ITAD
Integrin alpha-D

1

5

High-throughput

0.691

High

580772

EPHA7
Ephrin type-A receptor 7

1

13

High-throughput

0.691

High

580776

MICB
MHC class I polypeptide-related sequence B

1

4

High-throughput

0.691

High

580783

SDK2
Protein sidekick-2

1

9

High-throughput

0.691

High

580811

NECT2
Nectin-2

1

17

High-throughput

0.691

High

580815

ASIC4
Acid-sensing ion channel 4

1

3

High-throughput

0.691

High

580832

ULBP3
UL16-binding protein 3

1

4

High-throughput

0.691

High

580844

CBLN4
Cerebellin-4

1

4

High-throughput

0.691

High

580851

BTNL2
Butyrophilin-like protein 2

1

17

High-throughput

0.691

High

580853

CLC4A
C-type lectin domain family 4 member A

1

10

High-throughput

0.691

High

580841

TMPS4
Transmembrane protease serine 4

1

9

High-throughput

0.665

High

547960

PSPC
Surfactant protein C

3

1

High-throughput

0.665

High

580846

PA2G3
Group 3 secretory phospholipase A2

1

0

High-throughput

0.663

High

580768

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.656

High

580809

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.656

High

515856

PEPA4
Pepsin A-4

2

0

High-throughput

0.655

High

580748

EP3B
Epididymal secretory protein E3-beta

2

0

High-throughput

0.655

High

580838

HHATL
Protein-cysteine N-palmitoyltransferase HHAT-like protein

2

0

High-throughput

0.655

High

580787

BRID5
BRICHOS domain-containing protein 5

3

3

High-throughput

0.647

High

580771

NECT1
Nectin-1

1

17

Small-scale

0.647

High

580762

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

20

High-throughput

0.646

High

580775

NTRK3
NT-3 growth factor receptor

1

14

High-throughput

0.646

High

290850

PPM1B
Protein phosphatase 1B

3

0

High-throughput

0.634

High

144160

UBE2C
Ubiquitin-conjugating enzyme E2 C

2

3

High-throughput

0.628

High

183125

GNPAT
Dihydroxyacetone phosphate acyltransferase

2

1

High-throughput

0.628

High

580736

RYK
Tyrosine-protein kinase RYK

2

18

High-throughput

0.628

High

580745

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

2

1

High-throughput

0.628

High

580758

EFNB1
Ephrin-B1

2

3

High-throughput

0.628

High

580796

NLRX1
NLR family member X1

2

4

High-throughput

0.628

High

580837

XPO5
Exportin-5

2

1

High-throughput

0.628

High

482230

PAEP
Glycodelin

1

1

High-throughput

0.618

High

580778

CEA21
Cell adhesion molecule CEACAM21

1

15

High-throughput

0.618

High

580842

HELLS
Lymphoid-specific helicase

1

1

High-throughput

0.618

High

188807

TMPS2
Transmembrane protease serine 2

1

9

High-throughput

0.618

High

413122

P53
Cellular tumor antigen p53

1

3

High-throughput

0.618

High

580791

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

580794

TM11B
Transmembrane protease serine 11B

1

9

High-throughput

0.618

High

580828

ACE2
Angiotensin-converting enzyme 2

1

1

Small-scale

0.618

High

580753

KR108
Keratin-associated protein 10-8

3

20

High-throughput

0.616

High

580737

TACT
T-cell surface protein tactile

2

1

High-throughput

0.611

High

231792

MFS11
UNC93-like protein MFSD11

2

1

High-throughput

0.606

High

327158

ZFPL1
Zinc finger protein-like 1

2

3

High-throughput

0.606

High

328624

VAMP5
Vesicle-associated membrane protein 5

2

2

High-throughput

0.606

High

580789

OLFM4
Olfactomedin-4

2

2

High-throughput

0.606

High

580805

ZDH22
Palmitoyltransferase ZDHHC22

2

2

High-throughput

0.606

High

580744

MAP2
Methionine aminopeptidase 2

2

0

High-throughput

0.602

High

580777

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

2

0

High-throughput

0.602

High

580802

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.602

High

580808

RETR2
Reticulophagy regulator 2

2

0

High-throughput

0.602

High

580822

XPO6
Exportin-6

2

0

High-throughput

0.602

High

580843

LANC2
LanC-like protein 2

2

0

High-throughput

0.602

High

580856

ALG5
Dolichyl-phosphate beta-glucosyltransferase

2

0

High-throughput

0.602

High

580852

FBX2
F-box only protein 2

2

8

High-throughput

0.601

High

516959

NT2NC
Notch homolog 2 N-terminal-like protein C

1

20

High-throughput

0.594

High

74150

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

144401

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

580734

TSPO
Translocator protein

2

0

High-throughput

0.580

High

580747

BI1
Bax inhibitor 1

2

0

High-throughput

0.580

High

580749

T2R19
Taste receptor type 2 member 19

2

0

High-throughput

0.580

High

580760

PLP2
Proteolipid protein 2

2

0

High-throughput

0.580

High

580782

CTXN3
Cortexin-3

2

0

High-throughput

0.580

High

580784

TTMP
TPA-induced transmembrane protein

2

0

High-throughput

0.580

High

580785

SNP47
Synaptosomal-associated protein 47

2

0

High-throughput

0.580

High

580786

TMM65
Transmembrane protein 65

2

0

High-throughput

0.580

High

580800

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.580

High

580806

T229B
Transmembrane protein 229B

2

0

High-throughput

0.580

High

580813

TMM54
Transmembrane protein 54

2

0

High-throughput

0.580

High

580816

RUSF1
RUS family member 1

2

0

High-throughput

0.580

High

580827

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

342504

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.578

High

580854

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.578

High

480679

LEG1
Galectin-1

1

10

High-throughput

0.575

High

580799

SPA12
Serpin A12

1

2

High-throughput

0.575

High

580819

MF14A
Hippocampus abundant transcript 1 protein

1

3

High-throughput

0.575

High

580840

FBX6
F-box only protein 6

2

8

High-throughput

0.571

High

70105

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.553

High

580743

HXA1
Homeobox protein Hox-A1

2

5

High-throughput

0.553

High

580763

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

580798

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.553

High

580825

TMM79
Transmembrane protein 79

2

1

High-throughput

0.553

High

580829

KRA93
Keratin-associated protein 9-3

2

20

High-throughput

0.553

High

580830

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.553

High

580831

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.553

High

580855

INSI2
Insulin-induced gene 2 protein

2

2

High-throughput

0.553

High

231297

EFNA2
Ephrin-A2

1

3

High-throughput

0.536

High

580738

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.536

High

580759

IL5RA
Interleukin-5 receptor subunit alpha

1

8

High-throughput

0.536

High

580823

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

2

High-throughput

0.536

High

580849

SLAF8
SLAM family member 8

1

15

High-throughput

0.536

High

580756

DYLT1
Dynein light chain Tctex-type 1

1

0

Small-scale

0.529

High

580752

KR107
Keratin-associated protein 10-7

1

20

High-throughput

0.523

High

580754

KR109
Keratin-associated protein 10-9

1

20

High-throughput

0.523

High

505796

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

3

High-throughput

0.514

High

164518

TNPO2
Transportin-2

1

0

High-throughput

0.513

High

580732

CTNA2
Catenin alpha-2

1

0

High-throughput

0.513

High

580733

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.513

High

580742

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.513

High

580850

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.513

High

517279

TM276
Transmembrane protein 276

1

0

High-throughput

0.493

High

580731

COT2
COUP transcription factor 2

1

5

High-throughput

0.489

High

580817

FXL20
F-box/LRR-repeat protein 20

1

3

High-throughput

0.489

High

474

NBPFJ
NBPF family member NBPF19

1

5

High-throughput

0.481

High

399537

VTNC
Vitronectin

1

0

Small-scale

0.480

High

217781

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

580757

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

580761

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

6

Small-scale

0.479

High

580788

LMBRL
Protein LMBR1L

1

4

High-throughput

0.479

High

580835

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

6

Small-scale

0.479

High

580845

T106B
Transmembrane protein 106B

1

3

High-throughput

0.479

High

580769

I13R2
Interleukin-13 receptor subunit alpha-2

1

10

High-throughput

0.445

High

580795

RBM23
Probable RNA-binding protein 23

1

3

High-throughput

0.445

High

580804

SIGL1
SIGLEC family-like protein 1

1

2

High-throughput

0.445

High

580810

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

580751

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

580858

AP1M2
AP-1 complex subunit mu-2

1

1

Small-scale

0.439

High

170645

CLGN
Calmegin

1

10

High-throughput

0.407

High

269988

XYLK
Glycosaminoglycan xylosylkinase

2

0

High-throughput

0.328

High

580739

RFC3
Replication factor C subunit 3

2

0

High-throughput

0.328

High

580790

MMS22
Protein MMS22-like

2

0

High-throughput

0.328

High

580834

ARV1
Protein ARV1

2

0

High-throughput

0.328

High

580770

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

580801

SYS1
Protein SYS1 homolog

2

0

High-throughput

0.316

High

580807

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

2

0

High-throughput

0.316

High

580814

S35B4
Nucleotide sugar transporter SLC35B4

2

0

High-throughput

0.316

High

580820

ZDH15
Palmitoyltransferase ZDHHC15

2

0

High-throughput

0.316

High

580833

TM6S2
Transmembrane 6 superfamily member 2

2

0

High-throughput

0.316

High

231442

ORC4
Origin recognition complex subunit 4

2

0

High-throughput

0.313

High

580779

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025