HitPredict

Interactor 1: PSA7 (O14818)
Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4)
Gene: PSMA7

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	36357363, 35256949, 23503661, 15987638
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid pooling approach, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 465
+	Hs
		242348 PSMA8_HUMAN (3-230): 3.67e-98: 288: 82.91		PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00
+	Hs
		240819 PSA5_HUMAN (3-232): 1.1e-94: 279: 35.32		PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00
+	Hs
		241252 PSA6_HUMAN (2-236): 1.76e-93: 276: 32.64		PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00
+	Hs
		240793 PSA1_HUMAN (3-244): 4.9e-93: 275: 32.11		PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00
+	Hs
		240794 PSA2_HUMAN (3-232): 1.61e-48: 161: 37.87		PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00
+	Hs
		680938 PSA1_HUMAN (3-244): 4.9e-93: 275: 32.11		CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81
+	Hs
		954897 PSA6_HUMAN (2-236): 1.76e-93: 276: 32.64		HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36
+	Hs
		681010 PSA1_HUMAN (3-244): 4.9e-93: 275: 32.11		HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36
+	At
		307134 PSA6B_ARATH (2-236): 3.22e-104: 303: 35.98		UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17
+	At
		307131 PSA6A_ARATH (2-236): 4.84e-94: 277: 36.82		UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17
+	At
		201186 PSA7B_ARATH (3-229): 3.55e-93: 275: 68.12		UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17
+	At
		718232 PSA7A_ARATH (3-229): 3.08e-92: 273: 68.56		UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17
+	At
		307138 PSA4A_ARATH (3-242): 2.59e-91: 271: 34.27		UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17
+	At
		200646 PSA2A_ARATH (3-233): 2.33e-91: 270: 37.77		UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17
+	Hs
		507087 PSA2_HUMAN (3-232): 1.61e-48: 161: 37.87		UBB_HUMAN (1-234): 4.43e-61: 200: 17.92
+	At
		1167715 PSA2B_ARATH (3-233): 5.28e-52: 170: 38.14		UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17