HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSMA8 (Q8TAA3)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
Gene: PSMA8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010498 - proteasomal protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 256
+	Hs
		165211 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA7_HUMAN (5-238): 2.03e-101: 297: 82.91
+	Hs
		241252 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA6_HUMAN (2-243): 1.55e-91: 272: 29.27
+	Hs
		240819 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA5_HUMAN (3-240): 2.24e-91: 271: 36.74
+	Hs
		240793 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA1_HUMAN (3-249): 1.11e-89: 267: 31.08
+	Hs
		240796 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA4_HUMAN (1-237): 2.55e-89: 266: 34.84
+	Hs
		240794 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA2_HUMAN (1-240): 6.61e-46: 155: 39.51
+	Hs
		680938 CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81		PSA1_HUMAN (3-249): 1.11e-89: 267: 31.08
+	Hs
		954897 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		PSA6_HUMAN (2-243): 1.55e-91: 272: 29.27
+	Hs
		681010 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		PSA1_HUMAN (3-249): 1.11e-89: 267: 31.08
+	Hs
		507088 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		PSA4_HUMAN (1-237): 2.55e-89: 266: 34.84
+	At
		307134 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA6B_ARATH (2-243): 6.67e-94: 277: 32.11
+	At
		307131 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA6A_ARATH (2-243): 5.13e-93: 275: 33.33
+	At
		201186 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA7B_ARATH (3-237): 1.13e-91: 272: 64.98
+	At
		307138 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA4A_ARATH (1-239): 1.71e-91: 272: 35.63
+	At
		718232 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA7A_ARATH (3-237): 1.55e-90: 269: 64.14
+	At
		200646 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA2A_ARATH (3-241): 3.21e-89: 265: 37.76
+	Hs
		507087 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		PSA2_HUMAN (1-240): 6.61e-46: 155: 39.51
+	At
		1167715 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA2B_ARATH (3-241): 2.88e-49: 163: 38.59